Human herpes virus reactivations and dynamic cytokine profiles in patients with cutaneous adverse drug reactions --a prospective comparative study

Allergy
Y-C ChenC-Y Chu

Abstract

Sequential human herpes virus (HHV) reactivation is well known in drug reaction with eosinophilia and systemic symptom (DRESS), but such a phenomenon has seldom studied in other types of cutaneous adverse drug reactions (cADRs). Moreover, the association between viral reactivations and cytokine or chemokine changes is largely unknown. We aimed to evaluate the viral reactivation rates of HHV-6, HHV-7, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in different cADRs and their impacts on clinical prognosis. Cytokine and chemokine changes with viral reactivations were also examined. A prospective study was conducted to monitor the viral statuses of patients with different cADRs by polymerase chain reaction and serum-specific antibody titers. Changes in plasma cytokine and chemokine levels were also evaluated by sequential blood samples. Among the various cADRs, HHV-6 reactivation was only observed in DRESS, but EBV and CMV could be detected in other cADRs. Many proinflammatory cytokines and chemokines, including interleukin (IL)-1β, IL-2, IL-6, interferon-γ, tumor necrosis factor-α, were significantly lower in DRESS patients with HHV-6 reactivation when compared to those without HHV-6 reactivation. In addition, these mediator...Continue Reading

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Citations

May 20, 2015·Journal of Medical Virology·Francesco BroccoloFrancesco Drago
Sep 5, 2015·Clinical and Translational Allergy·Rik SchrijversPascal Demoly
Jul 27, 2015·Current Opinion in Immunology·Bianca Schaub, Donata Vercelli
Feb 22, 2017·The Journal of Allergy and Clinical Immunology·Andrew SullivanDean J Naisbitt
Jun 10, 2017·International Journal of Molecular Sciences·Yung-Tsu ChoChia-Yu Chu
Mar 4, 2017·The British Journal of Dermatology·N R AdlerE J Phillips
Apr 28, 2020·The British Journal of Dermatology·T Bellón, S H Kardaun
Jun 22, 2021·Expert Opinion on Drug Metabolism & Toxicology·Thawinee JantararoungtongChonlaphat Sukasem
May 16, 2020·Journal of the American Academy of Dermatology·Nima Milani-NejadBenjamin H Kaffenberger

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