Human herpesvirus-6 and human herpesvirus-7 infections in bone marrow transplant recipients

Journal of Medical Virology
P K ChanM H Ng

Abstract

Human cytomegalovirus (HCMV), human herpesvirus-6 (HHV-6), and human herpesvirus-7 (HHV-7) DNA in peripheral blood leukocytes (PBL) of 61 bone marrow transplant recipients was monitored weekly during the first 12 weeks post-transplantation by a nested polymerase chain reaction (PCR). Thirty-seven (61%), 17 (28%), and 32 (53%) of patients had one or more PBL specimens positive for HCMV, HHV-6 or HHV-7 DNA, respectively. HHV-7 DNA in PBL during the early post-transplant period was associated with a longer time to neutrophil engraftment (mean 28.8 days vs 19.8 days; P = 0.01). In two patients who failed to engraft, HHV-6 DNA and HHV-7 DNA was detected in plasma and PBL, respectively, early in their post-transplant period. Patients with HCMV disease were more likely to have concurrent HHV-7 DNA in PBL prior to onset of disease than were patients with asymptomatic HCMV infection, suggesting that HHV-7 may be a cofactor in the progression from HCMV infection to HCMV disease. In the 17 patients (179 specimens) in whom viral DNA in plasma was studied (in addition to PBL), a positive result was found only in 3. In each, viral DNA in plasma appeared to correlate with clinically significant disease. HHV-7 DNA in plasma was associated with...Continue Reading

References

Aug 21, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Agnieszka TomaszewskaBożena Mariańska
Aug 14, 2001·Journal of Clinical Microbiology·A M KearnsA R Gennery
Jan 25, 2000·Journal of Clinical Pathology·P K ChanA F Cheng
Jan 18, 2005·Clinical Microbiology Reviews·Leen De BolleErik De Clercq
May 31, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Tomasz DzieciątkowskiMirosław Luczak
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Barbara ZawilinskaMagdalena Kosz-Vnenchak
Sep 28, 2002·The Journal of Infectious Diseases·P Ljungman
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B M Imbert-MarcilleN Milpied
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina Singh
Jul 26, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Henri Agut
Mar 6, 2008·Neuroimaging Clinics of North America·Nail Bulakbasi, Murat Kocaoglu
Feb 6, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Danielle M Zerr
Oct 14, 2004·The Journal of Pediatrics·Robert F Pass
Sep 8, 2006·Journal of Virological Methods·Julian SassenscheidtDirk Bandt
Apr 15, 2003·Neurologic Clinics·Amy A Pruitt
Dec 17, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nuria TormoDavid Navarro
Jan 16, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Akiko YamaneShinichiro Okamoto
Jan 21, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·David MetzgarGeorge Schneider
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N Singh
Aug 20, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L PerssonU Tidefelt
Aug 3, 2004·Revista Do Instituto De Medicina Tropical De São Paulo·Ronaldo B FreitasAlexandre C Linhares
Apr 5, 2001·Current Infectious Disease Reports·Nina Singh
Nov 15, 2001·Annals of Neurology·M S WainwrightD V Lewis
Oct 31, 2000·Journal of Medical Virology·P K ChanA F Cheng
Dec 1, 1999·Reviews in Medical Virology·J B Black, P E Pellett
Oct 27, 1999·Journal of Medical Virology·P K ChanA F Cheng
Jul 12, 2002·Hematological Oncology·K Y Yuen, P C Y Woo
Sep 11, 2003·Journal of Medical Virology·Paul K S ChanAugustine F Cheng
Feb 9, 2005·Pediatric Blood & Cancer·Helena SavolainenKim Vettenranta
May 3, 2005·Current Opinion in Infectious Diseases·K Ward
Jan 24, 2008·Transplantation·Andrés AntónMaría Angeles Marcos
Nov 15, 2002·International Journal of Hematology·Duncan A Clark
Sep 28, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Tomasz DzieciątkowskiGrażyna Młynarczyk
Jun 19, 2002·American Journal of Clinical Dermatology·Werner Kempf
Mar 18, 2006·Pediatric Blood & Cancer·Muhammad KhananiAdam Gassas
Sep 11, 1999·Scandinavian Journal of Infectious Diseases·G De Almeida RodriguesM De Magalhães-Silverman
Feb 13, 2003·Pediatric Transplantation·T Yoshikawa
Jul 1, 2008·Bone Marrow Transplantation·P LjungmanEuropean Conference on Infections in Leukemia

Citations

May 28, 1992·The New England Journal of Medicine·P PruksananondaT R Dambaugh
Jul 1, 1990·The Journal of Infectious Diseases·H KikutaS Matsumoto
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N FrenkelC H June
Sep 1, 1990·The Journal of Infectious Diseases·W H Burns, G R Sandford
Aug 12, 1989·Lancet·S K RusslerD R Carrigan
May 18, 1989·Nature·S Kwok, R Higuchi
Feb 14, 1987·Lancet·D Scheffner, S König
Aug 15, 1987·Lancet·R G DowningB E Griffin
May 7, 1988·Lancet·M BriggsR S Tedder
Mar 1, 1986·The Journal of Pediatrics·D EngelhardR A Good
Jul 1, 1994·The Journal of Pediatrics·K TanakaK Yamanishi
May 1, 1994·Journal of Medical Virology·H O KangroM H Ng
Sep 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A McCullersR J Whitley
Sep 1, 1995·Journal of Medical Virology·F WilbornW Siegert
Dec 1, 1995·Journal of Medical Virology·E G Lyall, H A Cubie
May 1, 1996·Journal of Medical Virology·R InagiK Yamanishi
Aug 1, 1996·The Journal of Pediatrics·S TorigoeK Yamanishi
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·G C KatsafanasN Frenkel
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K K Knox, D R Carrigan
Jan 1, 1996·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·C Mylonas

Related Concepts

Graft Acceptance
Simplexvirus
Human Herpesvirus 6 Encephalitis
Graft-vs-Host Disease
DNA, Viral
Bone Marrow
Human Herpesvirus 5 species
Herpesviridae Infections
Longitudinal Survey
Encephalitis

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.