Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study.

Brain Pathology
R Alvarez-LafuenteR Arroyo

Abstract

This study was undertaken in order to investigate the possible relation of HHV-6 and EBV in relapsing-remitting MS (RRMS). A one-year follow up study was performed analysing peripheral blood mononuclear cells and serum samples of 57 patients with RRMS and 57 healthy blood donors (HBD) by a quantitative real time PCR, to detect HHV-6 and EBV. Clinical data (starting age and EDSS increase) were collected. We did not find any statistically significant difference for EBV between RRMS patients and HBD. Regarding HHV-6: i) There was a higher prevalence of HHV-6 in RRMS patients than in controls: 80.7% versus 29.8% respectively. ii) HHV-6 active replication seems to be related to exacerbations. iii) Only variant A was detected among RRMS patients with HHV-6 active replication. iv) Although some difference was found when we compared clinical data in RRMS patients with and without HHV-6 active replication, the results did not reach statistical significance. A higher HHV-6A frequency of active infection (reactivation or new infection) would lead to a more frequent exposure of HHV-6A antigens to the immune system of RRMS patients; this active replication of HHV-6A seems to be specifically related with the exacerbations in a subset of RRMS...Continue Reading

References

Nov 11, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z N BernemanR C Gallo
Oct 31, 1986·Science·S F JosephsR C Gallo
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·H V Vinters
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Nov 1, 1995·Neurology·I R MackenzieC A Wiley
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P B ChallonerM Chang
Jan 1, 1995·Acta Neurologica Scandinavica. Supplementum·J F Kurtzke
Feb 1, 1993·Journal of Medical Virology·M PortolaniA M Sabbatini
Jul 1, 1997·Clinical Microbiology Reviews·D K BraunP E Pellett
Apr 29, 1998·Journal of Virology·P MirandolaD Di Luca
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P D ColeN A Kernan
May 26, 1999·Emerging Infectious Diseases·G Campadelli-FiumeL Menotti
Sep 9, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·D L PatersonI R Marino
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·A RotolaD Di Luca
Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·B M BlumbergA D Goodman
Sep 7, 2000·The Journal of Comparative Neurology·T D PalmerF H Gage
Nov 4, 2000·Journal of Clinical Microbiology·G LocatelliM S Malnati
May 5, 2001·Epidemiology·C Wolfson
May 29, 2001·Journal of Clinical Microbiology·G Van den BoschZ N Berneman
Jan 5, 2002·JAMA : the Journal of the American Medical Association·A AscherioD J Hunter
Mar 21, 2002·Acta Neurologica Scandinavica·R Alvarez-LafuenteR Arroyo
Jun 18, 2002·Archives of Neurology·Roberto Alvarez-LafuenteRafael Arroyo González
Jul 18, 2002·Multiple Sclerosis : Clinical and Laboratory Research·J HongJ Z Zhang
Nov 19, 2002·Journal of Medical Virology·Svetlana ChapenkoModra Murovska
Jan 31, 2003·Annals of Neurology·Maria V Tejada-SimonJingwu Z Zhang
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Lynn I LevinAlberto Ascherio
May 23, 2003·Current Neurology and Neuroscience Reports·I A Scarisbrick, M Rodriguez
Jul 11, 2003·The New England Journal of Medicine·Hartmut Wekerle, Reinhard Hohlfeld
Aug 26, 2004·Multiple Sclerosis : Clinical and Laboratory Research·A RotolaE Cassai
Oct 13, 2004·Archives of Neurology·Roberto Alvarez-LafuenteRafael Arroyo
Jan 26, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H-J WagnerA Ascherio
Apr 6, 2005·Trends in Neurosciences·Berislav V Zlokovic
May 26, 2005·JAMA : the Journal of the American Medical Association·Lynn I LevinAlberto Ascherio

❮ Previous
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Citations

Jan 27, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Siobhan Ni Choileain, Anne L Astier
Jul 2, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J PietiläinenM Färkkilä
Aug 8, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R Alvarez-LafuenteR Arroyo
Apr 27, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M Garcia-MontojoUNKNOWN HHV-6 and Multiple Sclerosis Study Group
Aug 12, 2014·PloS One·Isabel Ortega-MadueñoRoberto Alvarez-Lafuente
Nov 7, 2013·Archives of Virology·Dharam AblashiTetsushi Yoshikawa
Dec 17, 2014·Clinical & Translational Immunology·Michael P Pender, Scott R Burrows
Nov 28, 2012·Journal of Neurovirology·Nadia Ben-FredjElisabetta Caselli
May 6, 2015·Acta Neurologica Scandinavica·L B LathamJ W Lindsey
Oct 12, 2010·Mayo Clinic Proceedings·Konstantine I VoumvourakisEleftherios Stamboulis
Jun 16, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Karen YaoSteven Jacobson
Oct 25, 2008·Clinical Neurology and Neurosurgery·Mayela Rodríguez-ViolanteTeresa Corona
Mar 26, 2009·Journal of Medical Virology·Matthew BatesUrsula A Gompels
May 22, 2009·Acta Neurologica Scandinavica·R Alvarez-LafuenteR Arroyo
Apr 1, 2009·Annals of Neurology·Karen YaoSteven Jacobson
Apr 21, 2007·Annals of Neurology·Alberto Ascherio, Kassandra L Munger
Feb 29, 2008·Annals of Neurology·Julio SoteloBenjamin Pineda
Jun 5, 2014·Acta Neurologica Scandinavica·S SimpsonI van der Mei
Sep 26, 2006·Trends in Microbiology·Charles W Stratton, David B Wheldon
Oct 3, 2012·Journal of Neuroimmunology·J W LindseyM S Guirguis
Jul 12, 2011·Immunobiology·Siobhan Ni Choileain, Anne L Astier
Mar 11, 2011·Diagnostic Microbiology and Infectious Disease·Enrique VillegasJosé Gutiérrez
Jul 16, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Almudena SantónJosé C Alvarez-Cermeño
Jun 1, 2013·Multiple Sclerosis : Clinical and Laboratory Research·J O VirtanenS Jacobson
Nov 16, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Steve SimpsonIngrid van der Mei
Sep 26, 2007·Multiple Sclerosis : Clinical and Laboratory Research·H KuusistoI Elovaara
Dec 24, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Roberto Alvarez-LafuenteRafael Arroyo
Oct 11, 2008·Multiple Sclerosis : Clinical and Laboratory Research·J W LindseyS Patel
Jun 21, 2008·Multiple Sclerosis : Clinical and Laboratory Research·R Alvarez-LafuenteR Arroyo
Nov 13, 2020·Clinical Microbiology Reviews·Anthony L KomaroffSteven Jacobson
Dec 19, 2018·Molecular Immunology·Elie DeebaChristina Christodoulou

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