Human herpesvirus-6 entry into host cells

Future Microbiology
Huamin Tang, Yasuko Mori

Abstract

Human herpesvirus-6 (HHV-6) belongs to the herpesvirus family and is categorized into variant A and B (HHV-6A and HHV-6B). Primary HHV-6 infection in children and its related diseases are almost exclusively caused by HHV-6B and no disease caused by HHV-6A has been identified. The cellular receptor of HHV-6 has been shown to be a human CD46, and its viral ligand is an envelope glycoprotein complex, gH/gL/gQ1/gQ2 in HHV-6A. Furthermore, both cellular and viral lipid rafts play an important role in the HHV-6 entry process, suggesting that HHV-6 may enter its target cells through a lipid raft-associated mechanism.

References

Jul 1, 1992·The Journal of General Virology·S YalcinK Yamanishi
Dec 1, 1992·AIDS Research and Human Retroviruses·M CironeA Faggioni
Jun 1, 1991·The Journal of General Virology·K KondoK Yamanishi
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E C SchirmerN Frenkel
Sep 8, 1990·Lancet·J D FoxR S Tedder
Jan 1, 1991·Archives of Virology·I WalevD Falke
Oct 1, 1990·The Journal of Infectious Diseases·L S WyattN Frenkel
Apr 1, 1989·Journal of Clinical Microbiology·T OkunoK Baba
Jul 1, 1989·Journal of Virology·K TakahashiK Yamanishi
Dec 1, 1989·The Journal of General Virology·K HigashiK Yamanishi
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M A Bratt, W R Gallaher
Mar 5, 1994·Lancet·K K Knox, D R Carrigan
Mar 1, 1994·Journal of Medical Virology·T MukaiK Yamanishi
Aug 18, 1994·The New England Journal of Medicine·C B HallL G Epstein
Feb 1, 1993·Journal of Medical Virology·M PortolaniA M Sabbatini
Oct 1, 1993·The Journal of General Virology·G Campadelli-FiumeL Foà-Tomasi
Feb 1, 1996·Journal of Virology·J HeC Wood
Oct 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N M van LoonS Dewhurst
Dec 1, 1996·Virus Research·C CermelliM Portolani
Jun 5, 1997·Nature·K Simons, E Ikonen
Jul 1, 1997·Clinical Microbiology Reviews·D K BraunP E Pellett
Dec 16, 1998·Journal of Virology·M LuppiG Torelli
Sep 11, 1999·Journal of Virology·Y IsegawaK Yamanishi
Jan 5, 2000·Cell·F SantoroP Lusso

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Citations

Jul 2, 2011·Journal of Neuro-oncology·Alexander KofmanRoger Abounader
Nov 7, 2013·Archives of Virology·Dharam AblashiTetsushi Yoshikawa
Dec 14, 2011·Cellular and Molecular Life Sciences : CMLS·Magdalena DomonJoanna Bandorowicz-Pikula
Jun 10, 2015·Human Genomics·M Kathryn Liszewski, John P Atkinson
Mar 26, 2015·Frontiers in Pharmacology·Sabrina M de MunnikHenry F Vischer
Jul 24, 2015·Journal of Virology·Huamin Tang, Yasuko Mori
Feb 23, 2021·Frontiers in Microbiology·Inés RipaRaquel Bello-Morales

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