Human herpesvirus-6 infection after liver transplantation

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Irmeli LautenschlagerEero Taskinen

Abstract

A diagnosis of posttransplantation human herpesvirus-6 (HHV-6) infection was established for eight adult recipients among a liver transplantation patient population of 121. The diagnosis was based on serology and demonstration of HHV-6 specific antigens in liver biopsy specimens with use of monoclonal antibodies and immunoperoxidase staining. A significant graft dysfunction was recorded in association with serodiagnosis. HHV-6 early antigens, as well as HHV-6 variant B antigens, were detected retrospectively in all six available liver biopsy specimens. Histologic examination of biopsy specimens demonstrated acute rejection in 5 of the 8 patients, and 3 patients had portal lymphocyte infiltration. In five cases cytomegalovirus (CMV) infection was associated with HHV-6 infection; in four cases CMV antigens were also detected in the biopsy specimens. Two patients who had pure HHV-6 infection without CMV infection or rejection had significantly impaired graft function, with a positive antigen-detection test. Thus, HHV-6 may infect the liver allograft and cause graft dysfunction and may possibly be associated with rejection and/or CMV infection.

References

Jun 1, 1988·The Journal of Infectious Diseases·C LopezP Feorino

❮ Previous
Next ❯

Citations

Nov 16, 2004·Journal of Medical Virology·N NishimuraT Iwasaki
Mar 20, 1999·Transplantation Proceedings·I LautenschlagerE Taskinen
Oct 26, 2002·Journal of Hepatology·Hans J Schlitt, Liwei Shi
Sep 15, 2000·Infectious Disease Clinics of North America·J D Fingeroth
Oct 4, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·I LautenschlagerK Höckerstedt
Sep 11, 2002·The Lancet Infectious Diseases·Francesca Cainelli, Sandro Vento
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D R Snydman
Feb 15, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S PastacaldiA K Burroughs
Aug 1, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Raymund R Razonable, Carlos V Paya
May 18, 2001·The New England Journal of Medicine·R K Avery
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B M Imbert-MarcilleN Milpied
Jun 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D R Snydman
Sep 28, 2002·The Journal of Infectious Diseases·Per Ljungman
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina Singh
Jul 26, 2000·Transplantation·I LautenschlagerK Höckerstedt
Aug 19, 2003·Transplantation·Maiju HärmäIrmeli Lautenschlager
Jan 18, 2005·Clinical Microbiology Reviews·Leen De BolleErik De Clercq
Jun 6, 2009·World Journal of Gastroenterology : WJG·Rima Camille Abdel Massih, Raymund R Razonable
Jan 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leena HalmeIrmeli Lautenschlager
May 11, 2012·Enfermedades infecciosas y microbiología clínica·Jordi CarratalàPilar Pérez-Romero
Feb 4, 2012·Journal of Virological Methods·Teemu KarlssonIrmeli Lautenschlager
May 15, 2010·Infectious Disease Clinics of North America·Ilkka HelanteräHans H Hirsch
Feb 6, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Raisa LoginovIrmeli Lautenschlager
Feb 6, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Per Ljungman, Nina Singh
Oct 27, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jun 21, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Ilkka HelanteräIrmeli Lautenschlager
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R R Razonable
Feb 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Irmeli Lautenschlager, Raymund R Razonable
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LeUNKNOWN AST Infectious Diseases Community of Practice
Jul 25, 2012·Journal of Medical Virology·Masaru IhiraTetsushi Yoshikawa
Sep 28, 2010·Journal of Medical Virology·Dharam V AblashiAnthony L Komaroff
May 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Marko LempinenIrmeli Lautenschlager
Feb 11, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S-O LeeR R Razonable

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.