Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation

Blood Advances
Coco C H de KoningJaap Jan Boelens

Abstract

Human herpesvirus 6 (HHV6) viremia is a common cause of morbidity following allogeneic hematopoietic cell transplantation (HCT). We previously associated T-cell reconstitution with HHV6 viremia. Here, we investigated whether HHV6 viremia affects T-cell reconstitution after HCT in a time-dependent retrospective analysis. We included 273 pediatric patients (0.1-22.7 years; median follow-up, 58 months) receiving a first HCT between 2004 and 2014. HHV6 was screened weekly in plasma via polymerase chain reaction and occurred in 79 patients (29%) at a median time of 19 days after transplant. Main outcome of interest was immune reconstitution (IR) (CD3/CD4/CD8 T cells), measured biweekly until 12 weeks and monthly thereafter. Cox proportional-hazard models were used with IR and HHV6 as time-dependent variables in multivariate analysis with serotherapy in conditioning, graft source, graft-versus-host disease, age, and other viruses (Epstein-Barr virus, cytomegalovirus, and adenovirus) as covariates. Only patients with very high HHV6 viremia (>105 copies/mL) showed hampered CD4+ (hazard ratio [HR], 0.913; 95% confidence interval [CI], 0.892-0.934; P < .001) and CD8+ (HR, 0.912; 95% CI, 0.891-0.933; P < .001) reconstitution in comparison...Continue Reading

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Citations

Jul 10, 2018·American Journal of Hematology·Tuan PhanDario Di Luca
Oct 1, 2019·Current Opinion in Infectious Diseases·Joshua A Hill
Nov 20, 2019·Journal of Clinical Medicine·Hyun Don YunClaudio Brunstein
Dec 14, 2018·Frontiers in Oncology·Eva EliassenStanley David Hudnall
Dec 6, 2019·Viruses·Joachim DennerBenedikt B Kaufer
Sep 9, 2020·The Journal of Clinical Investigation·Gunjan L ShahMiguel-Angel Perales
Feb 9, 2021·Frontiers in Immunology·Claudio AnnaloroFrancesco Onida
Apr 24, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tuan L PhanDanielle M Zerr
Aug 15, 2021·The Journal of Infectious Diseases·Yeon Joo LeeGenovefa Papanicolaou

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