Human herpesvirus-6 viremia is not associated with poor clinical outcomes in children following allogeneic hematopoietic cell transplantation

Pediatric Transplantation
Leah ViolagoPrakash Satwani

Abstract

HHV-6 is an evolving pathogen in the field of AlloHCT. However, the impact of HHV-6 on AlloHCT outcomes remains to be elucidated. We studied the incidence and clinical impact of HHV-6 viremia in children following AlloHCT. One hundred consecutive children were monitored weekly by plasma PCR for the first 180 days following AlloHCT for HHV-6, CMV, EBV, and ADV. HHV-6 viremia was defined as plasma PCR >1000 viral copies/mL. The median age was nine yr. Following AlloHCT, 19% (95% CI 11.3-26.7%) of patients had HHV-6 viremia, with the highest incidence of reactivation (14/19, 73%) occurring during day +15-day +98. The proportion of platelet engraftment by day +180 was lower in patients with HHV-6 viremia (58%) than in those without HHV-6 viremia (82%), p = 0.028. Delay in neutrophil and platelet engraftment was not associated with HHV-6 viremia in multivariate analysis. Similarly, HHV-6 viremia was not associated with TRM in multivariate analysis (p = 0.15). In summary, HHV-6 viremia is prevalent in pediatric AlloHCT recipients. Based on our study results, we recommend that HHV-6 PCR should only be performed on clinical suspicion.

References

Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A DesJardinD R Snydman
Mar 29, 2002·The Journal of Infectious Diseases·Tetsushi YoshikawaYukihiro Nishiyama
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Danielle M ZerrMichael Boeckh
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·P J Anne de PagterJaapJan Boelens
May 30, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Danielle M ZerrWendy M Leisenring
Jun 20, 2012·Current Opinion in Infectious Diseases·Danielle M Zerr

❮ Previous
Next ❯

Citations

Apr 11, 2017·The Journal of Allergy and Clinical Immunology·Rick AdmiraalJaap Jan Boelens
Mar 16, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Kotoe IesatoHiroyuki Tsutsumi
Oct 28, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Hiroki MiuraTetsushi Yoshikawa
Aug 30, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Anna B PawlowskaJoseph Rosenthal
Apr 24, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tuan L PhanDanielle M Zerr
Jul 27, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Armin RashidiDaniel J Weisdorf

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Li-Ru WangDao-Pei Lu
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
P J Anne de PagterJaapJan Boelens
The Israel Medical Association Journal : IMAJ
Yael Shachor-MeyouhasImad Kassis
© 2021 Meta ULC. All rights reserved