Human herpesvirus 6A infects human embryonic fibroblasts and induces G2/M arrest and cell death

Journal of Medical Virology
Lingyun LiKun Yao

Abstract

Human herpesvirus 6 (HHV-6) is a beta-herpesvirus capable of infecting cells from different origin. In this study, infection with HHV-6A of human embryonic fibroblasts (HEFs) was performed. Infected cells showed obvious cytopathic effects (CPE). PCR and immunohistochemical tests also confirmed that HEFs are susceptible to HHV-6A infection. The biological effects of HHV-6A infection on HEFs were studied. Infected cells showed decreased proliferation as measured by [(3)H] thymidine incorporation and cell counting. Further analysis demonstrated that infection with HHV-6A leads to cell cycle arrest at G2/M phase and increasing cell death. This is the first demonstration that infection of HEFs with HHV-6A causes profound alterations of cell properties.

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Citations

Jan 21, 2014·Infectious Agents and Cancer·Kenneth AlibekBolat Sultankulov
Oct 29, 2013·Future Virology·Lorenzo DagnaPaolo Lusso
Nov 23, 2013·Biotechnology Progress·A Contreras-GómezY Chisti
Feb 8, 2020·Viruses·Mikołaj WołącewiczPaulina Niedźwiedzka-Rystwej

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