Human Herpesvirus 6B Greatly Increases Risk of Depression by Activating Hypothalamic-Pituitary -Adrenal Axis during Latent Phase of Infection

IScience
Nobuyuki KobayashiKazuhiro Kondo

Abstract

Little is known about the effect of latent-phase herpesviruses on their host. Human herpesvirus 6B (HHV-6B) is one of the most ubiquitous herpesviruses, and olfactory astrocytes are one of the most important sites of its latency. Here, we identified SITH-1, an HHV-6B latent protein specifically expressed in astrocytes. Mice induced to produce SITH-1 in their olfactory astrocytes exhibited olfactory bulb apoptosis, a hyper-activated hypothalamic-pituitary-adrenal (HPA) axis and depressive symptoms. The binding of SITH-1 to the host protein calcium-modulating ligand (CAML) to form an activated complex promoted the influx of extracellular calcium. The serum antibody titers for depressive patients with respect to this activated complex were significantly higher than for normal controls (p = 1.78 × 10-15), when the antibody positive rates were 79.8% and 24.4%, respectively, and the odds ratio was 12.2. These results suggest that, in the latent phase, HHV-6B may be involved in the onset of depression.

Associated Datasets

Jun 2, 2020·Kazuhiro Kondo

Citations

Nov 21, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Masao OgataHikaru Kobayashi
Mar 7, 2021·International Journal of Molecular Sciences·Sandra SkujaModra Murovska
Mar 17, 2021·International Journal of Mental Health and Addiction·Yasuhiro KoteraMakoto Sakai
Jul 25, 2021·International Journal of Molecular Sciences·Daniel G SausenRonen Borenstein

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Datasets Mentioned

BETA
HV763913.1
HV763914.1

Methods Mentioned

BETA
two-hybrid
co-immunoprecipitation
immunoprecipitation
Co-immunoprecipitation assay

Software Mentioned

SOSUI

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