PMID: 9420276Jan 7, 1998Paper

Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription

Journal of Virology
J C ZimringM K Offermann

Abstract

Human herpesvirus 8 (HHV-8) is the probable viral etiologic agent for Kaposi's sarcoma. The HHV-8 genome encodes viral interferon regulatory factor (vIRF), a gene product that has homology to the IRF family of transcription factors. We demonstrate that vIRF inhibits responses to type I and type II interferons and blocks IRF-1-mediated transcription. vIRF does not compete with IRF-1 for binding to DNA or complex directly with IRF-1. The ability of vIRF to block IRF-1-mediated transcription is independent of the DNA binding domains of both vIRF and IRF-1. These data suggest that vIRF may contribute to viral pathogenesis and cellular transformation by interfering with interferon- and IRF-1-mediated gene expression through a novel mechanism.

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Citations

Feb 27, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J HiscottR Lin
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P S Moore, Y Chang
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Betsy BarnesPaula M Pitha
Jan 27, 2005·Viral Immunology·Friedemann WeberOtto Haller
Sep 1, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hye-Ra LeeJae U Jung
Sep 22, 2016·Critical Reviews in Biochemistry and Molecular Biology·Marni S CrowIleana M Cristea
Apr 30, 2017·Biological Chemistry·Sandra Koch, Thomas F Schulz
Mar 18, 1999·Pathology Oncology Research : POR·G MikalaI Vályi-Nagy
Jul 20, 2001·Journal of Virology·H NakamuraJ U Jung
Oct 12, 2000·Molecular and Cellular Biology·M LiJ U Jung
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Lyubomir A DourmishevDavid M Lukac
Jan 15, 2003·Annual Review of Medicine·David T Scadden
Sep 5, 2002·Nature Reviews. Immunology·Michael G KatzeMichael Gale
May 29, 2003·The Journal of General Virology·Charles CunninghamAndrew J Davison
Apr 11, 2014·Journal of Virology·Wadzanai P MbokoVera L Tarakanova
Mar 13, 2001·Annual Review of Immunology·T TaniguchiN Tanaka
May 13, 2003·Reviews in Medical Virology·Zhi-Ming Zheng
Nov 1, 2002·Reviews in Medical Virology·Bin GotohJunko Yokoo
Aug 31, 1999·The Journal of General Virology·F RoanM K Offermann
Nov 30, 2004·International Journal of Experimental Pathology·Shamindra Direkze, Heike Laman

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