Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor

Journal of Virology
Mildred Foster-CuevasA N Barclay

Abstract

Many viral proteins limit host immune defenses, and their genes often originate from their hosts. CD200 (OX2) is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) that is implicated in locally preventing macrophage activation. Distant, but recognizable, homologues of CD200 have been identified in many herpesviruses and poxviruses. Here, we show that the product of the K14 open reading frame from human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) interacts with human CD200R and is expressed at the surfaces of infected cells solely during the lytic cycle. Despite sharing only 40% primary sequence identity, K14 and CD200 interacted with CD200R with an almost identical and low affinity (K(D) = 0.5 microM), in contrast to other characterized viral homologue interactions. Cells expressing CD200 or K14 on the cell surface were able to inhibit secretion by activated macrophages of proinflammatory cytokines such as tumor necrosis factor alpha, an effect that could be specifically relieved by addition of monoclonal antibodies and soluble monomeric CD200 protein. We conclude that CD200 delivers local down-modulatory signals to myeloid cells through direct cell-cell contact ...Continue Reading

References

Oct 1, 1984·Journal of Neurochemistry·M Webb, A N Barclay
Mar 31, 1995·Journal of Molecular Biology·D J McGeochE A Telford
Jan 1, 1996·Annual Review of Immunology·M K Spriggs
Apr 1, 1996·Current Opinion in Immunology·P A van der Merwe, A N Barclay
Aug 1, 1997·European Journal of Immunology·S PrestonM H Brown
Jan 7, 1998·Immunological Reviews·G L SmithA Alcamí
Dec 8, 1998·The Journal of Experimental Medicine·M H BrownA N Barclay
Feb 11, 1999·Journal of Virology·R SunG Miller
May 27, 1999·Seminars in Cancer Biology·D J McGeoch, A J Davison
Dec 11, 1999·Nucleic Acids Research·J SchultzP Bork
Feb 9, 2000·The Journal of Experimental Medicine·E CesarmanM C Gershengorn
Jun 3, 2000·Annual Review of Immunology·D TortorellaH L Ploegh
Jul 8, 2000·Microbes and Infection·H GruffatE Manet
Oct 24, 2000·Journal of Virology·D J McGeochA C Ralph
Dec 1, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R M GorczynskiJ Hu
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gavin J WrightA Neil Barclay

❮ Previous
Next ❯

Citations

May 13, 2006·Nature Reviews. Immunology·A Neil Barclay, Marion H Brown
Apr 26, 2007·Nature Reviews. Immunology·Laurent Coscoy
Oct 8, 2005·Bioinformatics·Eddo Kim, Yossef Kliger
Jun 19, 2010·Nucleic Acids Research·Zhiqi ChenReginald M Gorczynski
Apr 8, 2011·Journal of Virology·Mildred Foster-CuevasSebastian Voigt
Jul 3, 2009·Journal of Virology·Leiliang ZhangGrant McFadden
Feb 28, 2006·Journal of Virology·Carly L LanglaisScott W Wong
Nov 17, 2007·The Journal of Clinical Investigation·Kimberly B PetermannNorman E Sharpless
Mar 3, 2005·BMC Biochemistry·Michelle LetarteA Neil Barclay
Aug 25, 2006·Critical Reviews in Immunology·Konstantinos Minas, Janet Liversidge
Sep 24, 2010·Future Microbiology·Hye-Ra LeeJae U Jung
Sep 27, 2012·Viruses·Gabrielle StackIan R Humphreys
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Weiguo CuiAgnès Vignery
Dec 8, 2009·Immunogenetics·Munir Akkaya, A Neil Barclay
Jan 17, 2015·Viruses·Pravinkumar PurushothamanSubhash C Verma
Dec 18, 2007·Expert Opinion on Biological Therapy·Anke Kretz-Rommel, Katherine S Bowdish
Nov 23, 2015·Virology·Munir AkkayaA Neil Barclay
Nov 6, 2015·The Journal of General Virology·Lai Shan KwongDeborah Hatherley
Jun 12, 2013·Current Opinion in Virology·Ryan D Estep, Scott W Wong
Jan 3, 2013·European Journal of Immunology·Munir Akkaya, A Neil Barclay
Dec 3, 2014·Virology·Abbas Ali AminiS A Rahim Rezaee
Feb 24, 2009·Trends in Microbiology·Cristina Aresté, David J Blackbourn
Nov 6, 2007·The Journal of Surgical Research·Reg GorczynskiIsmat Khatri
Dec 26, 2006·Molecular Immunology·Robert Jan Lebbink, Linde Meyaard
Mar 16, 2016·Seminars in Immunology·Dieke J van ReesTimo K van den Berg
Feb 21, 2009·Journal of Cellular Physiology·Cristiano SalataGiorgio Palù
Oct 25, 2008·Seminars in Cancer Biology·Chengyu LiangJae U Jung
Aug 4, 2007·Cancer Treatment and Research·Anita AroraStephen K Tyring
Jul 20, 2014·Cytokine & Growth Factor Reviews·Kevin Brulois, Jae U Jung
Nov 14, 2008·Immunity·A Neil Barclay, Deborah Hatherley
Jun 11, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Miguel CavadasRicardo Franco
Nov 30, 2006·FEMS Immunology and Medical Microbiology·Márta CsireIstván Vályi-Nagy
Sep 2, 2016·The Journal of Clinical Investigation·Dirk P Dittmer, Blossom Damania
Dec 8, 2007·Molecular Immunology·Birgit C ViertlboeckThomas W Göbel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.