Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity

Microbes and Infection
Esther van de Vosse, Tom H M Ottenhoff

Abstract

Interleukin (IL)-12/IL-23 signal transduction-deficient individuals with genetic defects in IL12RB1 or IL12B often suffer from unusual mycobacterial and Salmonella infections. Here we discuss recent questions that have arisen from clinical observations that cast doubt on the necessity of IL-12/IL-23 signaling in controlling infections with intracellular bacteria. Alternative IL-12/IL-23-dependent, interferon-gamma-independent pathways of immunity to intracellular bacteria are also discussed.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L FlynnB R Bloom
Sep 1, 1995·Research in Immunology·D H PreskyM K Gately
Jan 15, 2003·Journal of Leukocyte Biology·Carla S R Lankford, David M Frucht
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
Jun 5, 2003·European Journal of Immunology·Claire Fieschi, Jean-Laurent Casanova
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Orna Staretz-HahamJacov Levy
Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Isabel CaragolTeresa Español
Jan 30, 2004·Cytokine & Growth Factor Reviews·Djordje Miljkovic, Vladimir Trajkovic
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Frank A W VerreckTom H M Ottenhoff
Jun 15, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Marita BosticardoFabio Candotti
Oct 23, 2004·The Journal of Infectious Diseases·Calman MacLennanDinakantha S Kumararatne
Nov 30, 2004·The Lancet Infectious Diseases·Esther van de VosseTom H M Ottenhoff
Jan 22, 2005·Immunology and Cell Biology·Masato UchijimaYukio Koide
Feb 1, 2005·European Journal of Immunology·Serge Vanden EijndenMichel Goldman
Feb 13, 2007·Journal of Medical Genetics·Jacinta BustamanteJean-Laurent Casanova
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ciriana OrabonaPaolo Puccetti

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Citations

Jan 12, 2011·Journal of Clinical Immunology·Takayuki HoshinaToshiro Hara
Oct 15, 2013·The Journal of Infection·Margje H HaverkampJaap T van Dissel
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Seung-Joo LeeStephen J McSorley
Dec 18, 2008·International Immunology·Diederik van de WeteringEsther van de Vosse
Oct 6, 2007·Current Opinion in Rheumatology·Esther van de Vosse, Michiel A van Agtmael
May 2, 2012·The Journal of Clinical Investigation·Kai Soo TanYunn-Hwen Gan
Apr 28, 2010·Therapeutics and Clinical Risk Management·Nora KoutrubaMark Lebwohl
Dec 20, 2013·International Journal of Molecular Sciences·Shumin YuYanchun Hu
Jan 22, 2011·Gastroenterology Research and Practice·Lynnette R FergusonAngharad R Morgan
Jul 3, 2009·Expert Opinion on Biological Therapy·Xinaida Taligare LimaHermenio Cavalcante Lima
Jun 15, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Judith PotjewijdEsther van de Vosse
May 14, 2008·The Journal of Infection·Melita A Gordon
Jan 19, 2008·Clinical Biochemistry·Paul L A M CorstjensAnnemiek Geluk
Aug 20, 2010·Clinical Genetics·L E Cottle
Jul 19, 2013·Human Mutation·Esther van de VosseJacinta Bustamante
Jan 11, 2013·The British Journal of Dermatology·K A PappUNKNOWN ACCEPT Investigators
Mar 7, 2006·Microbes and Infection·Tom H M Ottenhoff
May 27, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth Huiwen ThamLynette Pei-Chi Shek
May 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·J YancoskiS D Rosenzweig
Sep 26, 2008·Clinical and Vaccine Immunology : CVI·M L V WatkinsS R Ress
Jul 1, 2020·Journal of Clinical Immunology·Seyed Alireza MahdavianiAli Akbar Velayati
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antonio Gigliotti RothfuchsAlan Sher
Oct 6, 2007·Current Opinion in Rheumatology
Oct 24, 2009·The Lancet Infectious Diseases·Esther van de VosseTom H M Ottenhoff

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