PMID: 6968293Jan 1, 1980Paper

Human IgE, IgG and IgE antibody synthesis in vitro

International Archives of Allergy and Applied Immunology
K OhtaH Maeda

Abstract

Human IgE biosynthesis in vitro was studied by co-culturing T and B cells from atopic patients and normal controls in the presence of 10 microliter/ml pokeweed mitogen for 7 days. IgE and anti-mite IgE ab in the culture media significantly correlated with those in plasma. Normal T cells suppressed in vitro production of IgE and IgE ab significantly more than did atopic T cells but no difference was found in IgG production. The culture of B cells alone (T-depleted fraction) produced IgE equally as well as the co-culture of T and B cells. Anti-mite IgE ab was also produced by B cells alone from mite-sensitive patients. However, IgE biosynthesis in vitro was not consistently affected by pokeweed mitogen. The results suggest a deficiency of the T suppressor system in atopy and the existence of T-independent IgE-producing cells.

Citations

Aug 1, 1995·European Journal of Immunology·S L HelmJ G Tew
Sep 1, 1989·International Journal of Dermatology·M H GoldH H Roenigk
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·M H SoesatyoS Sirisinha

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