Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer.

Journal of Neural Transmission
C GeisClaudia Sommer

Abstract

Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.

References

May 31, 1990·The New England Journal of Medicine·M SolimenaP De Camilli
Feb 25, 1993·The New England Journal of Medicine·F FolliP De Camilli
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy
Jun 16, 2005·Neurology·Rezvan AmeliMarinos C Dalakas
Nov 7, 2007·Journal of Neural Transmission. Supplementum·T WultschA Reif
Feb 13, 2009·Current Treatment Options in Neurology·Marinos C Dalakas
Oct 5, 2010·Brain : a Journal of Neurology·Christian GeisClaudia Sommer
Feb 25, 2011·PloS One·Christian GeisClaudia Sommer
Jul 13, 2011·Neurology·Eric LancasterJosep Dalmau
Jul 23, 2011·Lancet Neurology·Angela VincentPatrick Waters

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Citations

Oct 9, 2012·Current Opinion in Neurology·Francesc Graus, Josep Dalmau
Jun 22, 2014·Brain : a Journal of Neurology·Alexander Carvajal-GonzálezAngela Vincent
Oct 31, 2013·Expert Review of Clinical Immunology·Harry Alexopoulos, Marinos C Dalakas
Feb 26, 2016·Brain : a Journal of Neurology·Sarosh R Irani
Nov 20, 2015·Brain : a Journal of Neurology·Christian WernerChristian Geis
Dec 17, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·José Fidel Baizabal-Carvallo, Joseph Jankovic
Mar 22, 2018·Reviews in the Neurosciences·Karolina Popławska-DomaszewiczSławomir Michalak
Oct 8, 2020·Journal of Neural Transmission·Niels Hansen, Charles Timäus
Nov 26, 2020·Expert Opinion on Therapeutic Targets·Josefine SellChristian Geis
Apr 16, 2021·Therapeutic Advances in Neurological Disorders·Popianna TsiortouMarinos C Dalakas
Nov 30, 2021·BJPsych Bulletin·Karim Abdel AzizDanilo Arnone

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