PMID: 9651785Jan 1, 1997Paper

Human IgG Fc receptors

International Reviews of Immunology
I A Heijnen, J G van de Winkel

Abstract

Human IgG receptors constitute a family of glycoprotein complexes consisting of ligand-binding, and associated signaling chains. Three leukocyte classes (Fc gamma RI, II, and III) and one separate endothelial Fc gamma R class (FcRB) are defined which are expressed on hematopoietic and endothelial cells. Upon interaction with IgG, Fc gamma R initiate a plethora of signaling cascades involving receptor signaling motifs, and protein tyrosine kinases and phosphatases. These cascades ultimately culminate in activation or deactivation of effector cells, resulting in initiation or down-modulation of cellular processes. Recent evidence points to a crucial in vivo role of Fc gamma R in both initiation and regulation of inflammatory and cytotoxic responses. These Fc gamma R-mediated immune responses can be exploited to develop novel immunotherapies.

References

Nov 1, 1978·The Journal of Allergy and Clinical Immunology·A F GeczyO Toffler
Aug 1, 1992·The British Journal of Surgery·A R NaylorC V Ruckley
Nov 1, 1992·The Journal of Clinical Investigation·A J PorgesR P Kimberly
Apr 1, 1990·The Journal of Clinical Investigation·J E SalmonR P Kimberly
May 1, 1991·Journal of Leukocyte Biology·J G van de Winkel, C L Anderson
Nov 1, 1991·The Journal of Clinical Investigation·Z IndikA D Schreiber
Apr 1, 1990·The Journal of Experimental Medicine·C L AndersonJ K Gill
Mar 15, 1990·The New England Journal of Medicine·P RuizA D Schreiber
Mar 1, 1989·Immunology Today·M W FangerP M Guyre
Dec 1, 1989·The Journal of Allergy and Clinical Immunology·L M AnselminoL L Thomas
Jan 12, 1989·Nature·N E Simister, K E Mostov
Mar 30, 1989·Nature·M Reth
May 8, 1986·The New England Journal of Medicine·S B ClarksonJ C Unkeless
Jan 1, 1966·The Journal of Experimental Medicine·A Berken, B Benacerraf
Jan 1, 1981·International Archives of Allergy and Applied Immunology·A W van Toorenenbergen, R C Aalberse
Jun 1, 1984·Molecular Immunology·J M WoofD R Burton
Apr 1, 1984·Immunological Reviews·G J Prud'hommeA N Theofilopoulos
Oct 1, 1984·Biochemical Society Transactions·J M Woof, D R Burton
Jul 1, 1994·British Journal of Haematology·T W HuizingaA E von dem Borne
Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F H ValoneM Mrozek-Orlowski
Jul 1, 1995·Immunity·R Clynes, J V Ravetch
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·J G Park, A D Schreiber
Sep 8, 1995·The Journal of Biological Chemistry·M D HulettP M Hogarth
May 5, 1995·The Journal of Biological Chemistry·P J VossebeldA J Verhoeven
Feb 1, 1995·The Journal of Clinical Investigation·M DaëronW H Fridman
Feb 1, 1995·Immunology Today·J C Cambier
Oct 1, 1994·The Journal of Infectious Diseases·R G BrediusT A Out

❮ Previous
Next ❯

Citations

May 24, 2005·Leukemia Research·Romina GamberaleMirta Giordano
Sep 10, 2002·Molecular Immunology·Christine TkaczykDean D Metcalfe
Mar 4, 2000·Molecular Immunology·J Köhl, J E Gessner
Oct 2, 2001·Critical Reviews in Oncology/hematology·P M McLaughlinL F de Leij
Jul 22, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Antonia H M BoutsTheo A Out
Aug 22, 2003·Critical Care : the Official Journal of the Critical Care Forum·Andrew J E SeelyNicolas V Christou
Apr 28, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Antonia H M BoutsTheo A Out
Mar 24, 2009·Lancet·Louis M WeinerSoldano Ferrone
Nov 26, 2002·The Journal of Investigative Dermatology·Karla CauzaDagmar Foedinger
Mar 11, 2004·The Journal of Investigative Dermatology·Gabriele HinterhuberDagmar Foedinger
Jan 19, 2005·The Journal of Investigative Dermatology·Karla CauzaDagmar Foedinger
Oct 21, 2016·Scientific Reports·Fenfang WuAnlong Xu
Apr 19, 2008·Inflammatory Bowel Diseases·Farooq Z RahmanAnthony W Segal
Sep 10, 2005·Nature Biotechnology·Gregory P Adams, Louis M Weiner
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A BreukelsG T Rijkers
Nov 12, 2005·Journal of Leukocyte Biology·George SoaresJohan Van Weyenbergh
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yusuke SuzukiJesús Egido
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong TangLouis M Weiner
Feb 16, 2019·Frontiers in Immunology·Toine Ten BroekeJeanette H W Leusen
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernhard StockmeyerMartin Herrmann
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liat BinyaminLouis M Weiner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.