Human IgM anti-IgM cytotoxin for B lymphocytes

Tissue Antigens
J C CicciarelliS Shirahama

Abstract

B lymphocytes were shown previously to be killed at 5 degrees C by some autologous and allogeneic human sera. We show here that such cold cytotoxins are directed against immunoglobulins on the surface of B lymphocytes. The activity is partially removed by passing serum through IgG-coupled Sepharose and usually completely removed by passing serum through IgM-coupled Sepharose. Activity is regained from the columns by acid elution and IgM inhibits the cytotoxicity of these eluates. 125I-labeled eluates bind to IgG- and IgM-coupled Sepharose beads and binding is inhibited by IgM and to a lesser degree by IgG thus showing a primarily more avid binding to IgM as compared to IgG. Furthermore, the 125I-labeled cytotoxic eluates recognize the same determinant(s) on IgM and IgG. We suggest tht IgM anti-IgM antiimmunoglobulin may regulate immune reactivity by binding to B-lymphocyte surfaces.

References

Sep 3, 1977·Lancet·M S ParkD Bernoco
Feb 1, 1978·American Journal of Clinical Pathology·P I TerasakiY Iwaki
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J C CambierE S Vitetta
Jul 1, 1979·Tissue Antigens·G Ozturk, P I Terasaki
Oct 12, 1978·The New England Journal of Medicine·G Opelz, P I Terasaki
Jan 1, 1978·Scandinavian Journal of Immunology·G Möller
Jul 1, 1976·Arthritis and Rheumatism·I MalavéZ Layrisse
Jun 1, 1975·The Journal of Clinical Investigation·R J DeHoratius, R P Messner
Dec 7, 1975·The New England Journal of Medicine·S J KorsmeyerR G Strickland
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Oct 1, 1972·The Journal of Experimental Medicine·V A BokischR M Krause
Jul 25, 1972·Biochemical and Biophysical Research Communications·G S David
Nov 1, 1961·The Journal of Experimental Medicine·J L ABRUZZO, C L CHRISTIAN

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