Human Imaging With Photon Counting-Based Computed Tomography at Clinical Dose Levels: Contrast-to-Noise Ratio and Cadaver Studies

Investigative Radiology
R GutjahrCynthia McCollough

Abstract

The purpose of this work was to measure and compare the iodine contrast-to-noise ratio (CNR) between a commercial energy-integrating detector (EID) computed tomography (CT) system and a photon-counting detector (PCD) CT scanner capable of human imaging at clinical dose rates, as well as to determine clinical feasibility using human cadavers. A research dual-source PCD-CT scanner was used, where the "A" tube/detector subsystem used an EID and the "B" tube/detector subsystem used a PCD. Iodine CNR was measured in 4 anthropomorphic phantoms, simulating 4 patient sizes, at 4 tube potential settings. After biospecimen committee approval, PCD scans were performed on a fresh-frozen human head and a whole-body cadaver using clinical dose rates. Scans were repeated using the EID and identical parameters, and qualitative side-by-side comparisons were performed. For the same photon fluence, phantom measurements demonstrated a mean increase in CNR of 11%, 23%, 31%, 38% for the PCD system, relative to the EID system, at 80, 100, 120, and 140 kV, respectively. Photon-counting detector CT additionally provided energy-selective imaging, where low- and high-energy images reflected the energy dependence of the iodine signal. Photon-counting dete...Continue Reading

References

Jul 20, 2007·Physics in Medicine and Biology·E Roessl, R Proksa
Feb 26, 2008·Physics in Medicine and Biology·Polad M Shikhaliev
Sep 19, 2008·Physics in Medicine and Biology·Polad M Shikhaliev
Aug 14, 2009·Medical Physics·Taly Gilat Schmidt
Nov 19, 2009·IEEE Transactions on Nuclear Science·Jan S IwanczykJan C Wessel
Oct 4, 2012·Physics in Medicine and Biology·Thomas KoenigUwe Oelfke
Oct 5, 2013·Medical Physics·Katsuyuki Taguchi, Jan S Iwanczyk
Dec 11, 2013·Medical Physics·Robert E Alvarez
Jan 1, 2015·Investigative Radiology·Anke de VriesHolger Grüll
Aug 25, 2015·Radiology·Cynthia H McColloughJoel G Fletcher

❮ Previous
Next ❯

Citations

Mar 16, 2017·The International Journal of Cardiovascular Imaging·Rolf SymonsAmir Pourmorteza
Jul 7, 2017·PloS One·Darin P Clark, Cristian T Badea
Mar 30, 2018·Investigative Radiology·Amir PourmortezaDavid A Bluemke
Mar 30, 2018·Investigative Radiology·Nils Große HokampStefan Haneder
Aug 8, 2018·Radiology·Roy P MarcusCynthia H McCollough
Sep 5, 2018·Radiology·Martin J WilleminkDominik Fleischmann
Jun 28, 2017·Journal of Medical Imaging·Zhoubo LiCynthia H McCollough
Feb 14, 2019·European Radiology·Alexis LaugeretteFranz Pfeiffer
Sep 29, 2019·The British Journal of Radiology·Ross Edward TaylorNakul Gupta
Nov 28, 2018·Scientific Reports·Felix K KoppPeter B Noël
Nov 21, 2017·Journal of X-ray Science and Technology·Liqiang RenHong Liu
Nov 9, 2019·Physics in Medicine and Biology·Liqiang RenLifeng Yu
Sep 26, 2017·Investigative Radiology·Manoj MannilHatem Alkadhi
Jan 28, 2020·Investigative Radiology·Kishore RajendranCynthia H McCollough
Sep 20, 2019·PloS One·Darin P ClarkCristian T Badea
Mar 28, 2020·Medical Physics·Cynthia H McColloughNorbert J Pelc
Feb 26, 2020·Nature Reviews. Cardiology·Marc DeweyUNKNOWN Quantitative Cardiac Imaging Study Group
Jul 24, 2020·Investigative Radiology·Laura SchöckelHubertus Pietsch
Jun 6, 2020·Physics in Medicine and Biology·Shengzhen TaoShuai Leng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis