Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice

PloS One
Jessica R SpenglerChristina F Spiropoulou

Abstract

Rift Valley fever (RVF) in humans is usually mild, but, in a subset of cases, can progress to severe hepatic and neurological disease. Rodent models of RVF generally develop acute severe clinical disease. Here, we inoculated humanized NSG-SGM3 mice with Rift Valley fever virus (RVFV) to investigate whether the presence of human immune cells in mice would alter the progression of RVFV infection to more closely model human disease. Despite increased human cytokine expression, including responses mirroring those seen in human disease, and decreased hepatic viral RNA levels at terminal euthanasia, both high- and low-dose RVFV inoculation resulted in lethal disease in all mice with comparable time-to-death as unengrafted mice.

References

Jan 30, 2008·PLoS Pathogens·Nicolas Le MayMichèle Bouloy
Jan 28, 2009·Journal of Clinical Microbiology·M Kariuki NjengaRobert F Breiman
Sep 21, 2010·Virology·Darci R SmithLisa E Hensley
Nov 17, 2011·Virus Research·Ted M RossDarci R Smith
Sep 6, 2014·Cold Spring Harbor Perspectives in Biology·Toshio TanakaTadamitsu Kishimoto
Oct 7, 2015·Virology Journal·Petrus Jansen van VurenJanusz T Paweska
Dec 14, 2016·Annual Review of Pathology·Nicole C WalshLeonard D Shultz
May 10, 2017·The Journal of Infectious Diseases·Jessica R SpenglerChristina F Spiropoulou
Aug 16, 2017·Current Opinion in Virology·Jessica R SpenglerChristina F Spiropoulou

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Methods Mentioned

BETA
flow cytometry
xenograft

Software Mentioned

GraphPad Prism

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