Human immune interferon: induction in lymphoid cells by a calcium ionophore.

Infection and Immunity
F DianzaniJ B Alperin

Abstract

Human lymphocyte cultures produced interferon after treatment with the calcium ionophore A23187, but not after treatment with potassium ionophore nonactin. Interferon production was detectable between 3 and 6 h after ionophore treatment and reached the maximum level between 12 and 24 h. Ionophore-induced interferon appeared to be immune interferon on the basis of acid lability, lack of neutralization by antibody to leukocyte interferon, slow kinetics of activation of the antiviral state, and molecular characterization by isoelectrofocusing.

References

Oct 1, 1979·Infection and Immunity·M P LangfordH M Johnson
Oct 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·F DianzaniM Zucca
Jan 1, 1975·The Journal of Physiology·A G GarciaJ C Prat
Dec 1, 1974·FEBS Letters·G GrenierJ E Dumont
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May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R A Steinhardt, D Epel
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J R LuckasenJ H Kersey

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Citations

Jun 1, 1982·Infection and Immunity·F DianzaniM Santiano
Oct 1, 1981·Infection and Immunity·Y K YipJ Vilcek
Sep 1, 1984·Journal of Clinical Immunology·P M MatricardiF Aiuti
Jan 1, 1987·British Journal of Obstetrics and Gynaecology·S K TayA Singer

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