Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes

Nano Letters
M Saint-CricqW L Ling

Abstract

We atomistically compute the change in free energy upon binding of the globular domain of the complement protein C1q to carbon nanotubes (CNTs) and graphene in solution. Our modeling results imply that C1q is able to disaggregate and disperse bundles of large diameter multiwalled CNTs but not those of thin single-walled CNTs, and we validate this prediction with experimental observations. The results support the view of a strong binding with potential implications for the understanding of the immune response and biomedical applications of graphitic nanomaterials.

References

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Citations

Feb 19, 2019·Frontiers in Immunology·Bengt Fadeel
Oct 28, 2018·Nanomedicine : Nanotechnology, Biology, and Medicine·Agathe BelimeWai Li Ling
Sep 16, 2017·The Journal of Physical Chemistry. B·Agathe BelimeWai Li Ling

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