Jan 1, 1989

Human immune response against timothy grass pollen allergens. I. Shared idiotypes on human and murine antigen-B-specific lymphocyte receptors

International Archives of Allergy and Applied Immunology
A Malley

Abstract

Enzyme-linked immunoassays were used to examine the binding specificity of affinity-purified anti-idiotypic antibody [against the idiotypic determinant on timothy grass pollen antigen B (AgB)-specific IgE] with murine AgB-specific IgG and IgE antibodies, and the serum from timothy-sensitive patients. In addition, the proliferative response of peripheral blood lymphocytes from timothy-sensitive patients with either antigen or anti-idiotypic antibody was examined. These studies suggest that the idiotypic determinant expressed on murine AgB-specific IgE is highly conserved on human AgB-specific IgE and T cells of timothy-sensitive patients.

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Mentioned in this Paper

Monoclonal Antibodies
Immune Response
T-Lymphocyte
Timothy grass pollen
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Alopecurus
Receptors, Antigen, B-Cell
Cellobiose
Murine

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