PMID: 8470778Mar 1, 1993Paper

Human immune responses to the Plasmodium falciparum ring-infected erythrocyte surface antigen (Pf155/RESA) after a decrease in malaria transmission in Madagascar

The American Journal of Tropical Medicine and Hygiene
F MigotP Deloron

Abstract

A resurgence of falciparum malaria occurred in the central highlands of Madagascar in the 1980s and was responsible for an outbreak in 1986-1987. Since 1989, transmission has decreased dramatically. In April 1991, we investigated the humoral and cellular immune responses of 53 inhabitants of the village of Manarintsoa to six synthetic peptides that reproduced the major B and/or T cell epitopes of the Pfl 55/ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum. The presence of RESA peptide-reactive T cells was assessed by lymphocyte proliferation assay as well as by detection of in vitro production of interferon-gamma and interleukin-2. The mean values of these cellular responses were low, and the results obtained in these three tests showed no correlation. Twenty-seven subjects presented with anti-RESA antibodies as detected by modified immunofluorescent assay, but the mean levels of anti-peptide antibodies were low. When compared with data obtained in January 1988 from the same subjects with three of the six peptides, the present data demonstrated a decrease in the response to these peptides in terms of both proliferative response and mean antibody titers. The mean values of anti-RESA antibodies remained u...Continue Reading

Citations

May 23, 2002·Memórias do Instituto Oswaldo Cruz·Francisco José Dutra SoutoAna Maria Coimbra Gaspar
Jun 20, 2008·Nature Immunology·Jean LanghorneKevin Marsh
Jul 25, 2013·European Journal of Immunology·Francis M NdunguAnna Färnert
Jan 8, 2016·Parasitology·Freya J I FowkesJames G Beeson
Nov 17, 2019·Immunological Reviews·Damián Pérez-MazliahJean Langhorne
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Francis Maina NdunguKevin Marsh
Jan 9, 2016·Parasitology·Danielle I Stanisic, Michael F Good
Dec 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcela Montes de OcaChristian R Engwerda
Aug 14, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jane AchanUmberto D'Alessandro
Sep 14, 2004·Immunological Reviews·Siske S Struik, Eleanor M Riley
Jul 9, 2010·Journal of Leukocyte Biology·Matthew B B McCall, Robert W Sauerwein

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