Human immunodeficiency virus activity in rib allografts

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
S Marthy, M Richter

Abstract

The use of bone allografts involves the risk of transmitting infectious agents from the donor to the recipient as shown by historical surveys. A study was therefore undertaken to test the hypothesis that human immunodeficiency virus (HIV) activity can still be present after the freezing and thawing of ribs taken from an acquired immune deficiency syndrome (AIDS) patient at autopsy. Rib samples were harvested under sterile conditions and frozen at -80 degrees C. After different freezing periods, the samples were cultured with activated lymphocytes. P24 antigen determination in the supernatant fluid was used to test for viral activity. Confirmation of viral activity was obtained after freezing periods ranging from 1 to 12 weeks. HIV activity can be found in ribs of AIDS patients, and this outlives the cryoprotection of bone banking. Donor selection remains the main security in the use of frozen bone allografts.

References

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Citations

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Dec 4, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Peter A IndelicatoC Thomas Vangsness
Sep 9, 1999·Tissue Engineering·K U LewandrowskiD J Trantolo
Jul 17, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Roni KolermanHaim Tal
Apr 24, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A PrussW H Gerlich
Mar 4, 2006·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Lawrence A DiDomenico, Alfonso A Haro
Jan 31, 2014·The American Journal of Sports Medicine·Sam Si-Hyeong ParkJohn Theodoropoulos
Apr 2, 2004·Clinical Orthopaedics and Related Research·Pier Francesco IndelliDavid J Schurman

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