Human immunodeficiency virus and tuberculosis in Argentina: prevalence, genotypes and risk factors

Journal of Medical Microbiology
María A PandoMaria M Avila

Abstract

The objective of this study was to determine the prevalence and genetic variability of human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted infections (STIs) among 205 patients with clinical diagnosis of tuberculosis (TB) in Buenos Aires in 2001. Infections with hepatitis B virus (HBV), HIV-1, hepatitis C virus (HCV), Treponema pallidum and human T-cell lymphotropic virus types I/II were diagnosed in 37/187 (19.8 %), 35/205 (17.1 %), 22/187 (11.8 %), 13/187 (7.0 %) and 4/181 (2.2 %) patients, respectively. Almost one in three participants (33.1 %) presented at least one infection in addition to TB. Multiresistance to TB drugs (isoniazid plus rifampicin) was detected in the isolates recovered from three patients. Injecting drug use was detected as the main risk factor for HIV, HBV and HCV infections. Of ten patients who died, eight were infected with HIV. HIV genetic characterization showed the presence of two different subtypes. Env subtype F was found in 13/24 samples (54.2 %) and subtype B in 11/24 samples (45.8 %) by heteroduplex mobility assay. Sequencing of the protease/RT region was performed in ten samples: three were characterized as subtype B and seven as B/F recombinants by bootscanning analysis....Continue Reading

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Citations

Nov 26, 2011·AIDS Research and Human Retroviruses·Carolina A BeriniMirna M Biglione
Oct 25, 2012·Emerging Infectious Diseases·Viviana RitaccoLucía Barrera
Jul 12, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·María Sol Dos Ramos FaríasMaría Mercedes Avila
May 23, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·R S AiresR M B Martins
Feb 24, 2009·Lancet Neurology·Gustavo PradillaDaniele Rigamonti

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