Abstract
Clinical and pathological characteristics as well as outcome of 45 Hodgkin's disease (HD) cases collected by the French registry of HIV-associated tumors between January 1987 and December 1989 (all clinically staged according to the Ann Arbor system) were analyzed and compared with those of a cohort of 407 patients with clinical stages (CS) IA to IVB enrolled between September 1981 and August 1988 in a multicentric clinical trial. The route of HIV infection, initial CD4 cell count at the time of HD diagnosis and CDC class of HIV infection were studied as well as the progression to AIDS onset were recorded. HIV-HD is characterized by a predominance of advanced CS (75%), B symptoms (80%) and mixed cellularity histology (49%), as well as by early bone marrow involvement (24%); a specific feature is the rare occurrence of mediastinal involvement (13% in HIV-HD versus 71% in primary HD). With standard therapies, 79% of the patients achieved a complete remission, but hematological and infectious complications were very frequent. The proportion of intravenous drug abusers (IVDA) in HIV-HD (38%) is higher than in French HIV-infected population as a whole (20.8%). Median CD4 cell count was 306/microliters at the time of HD diagnosis, wh...Continue Reading
References
May 1, 1977·Scandinavian Journal of Haematology·M BjorkholmH Mellstedt
Feb 9, 1991·Lancet·G PallesenL S Young
Oct 5, 1991·Lancet·S RoithmannJ M Andrieu
Feb 1, 1991·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S MonfardiniF Gavosto
Apr 1, 1991·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S RoithmannB Dupont
May 1, 1990·Clinical and Experimental Immunology·A VenetJ M Andrieu
Mar 15, 1991·Cancer·H J ReeR Zalusky
Oct 15, 1990·International Journal of Cancer. Journal International Du Cancer·S UcciniL P Ruco
May 15, 1990·Cancer·M SerranoM Yebra
Aug 1, 1990·British Journal of Cancer·L J Bruce, B W Hancock
Jan 1, 1988·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·J M AndrieuB Desablens
May 1, 1988·Annals of Internal Medicine·D M KnowlesB Raphael
Jun 1, 1988·Cancer·D A LowenthalB Koziner
Oct 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D O DixonE A Gehan
Jan 15, 1994·Cancer·D ErranteS Monfardini
Jan 29, 1994·Lancet·J O'GradyA S Krajewski
Feb 15, 1993·Cancer·D S Karcher
Citations
Jun 8, 2001·Cancer·A KandilW A Mourad
Dec 26, 2001·Cancer·A ReG Rossi
Apr 27, 2000·Critical Reviews in Oncology/hematology·J L Hsu, S L Glaser
Jun 23, 2000·Critical Reviews in Oncology/hematology·H EghbaliP Richaud
Sep 14, 2001·Current Opinion in Oncology·C A Clarke, S L Glaser
Jun 26, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Falko Fend, Markus Kremer
Mar 15, 2006·Mayo Clinic Proceedings·Stephen M Ansell, James O Armitage
Dec 13, 2005·La Revue de médecine interne·F Bonnet, P Morlat
Jul 23, 2003·Cancer·Sally L GlaserRichard F Ambinder
Apr 20, 2007·The Cochrane Database of Systematic Reviews·A J Martí-CarvajalM L Rodríguez
Dec 13, 2002·AIDS·Laurence GérardEric Oksenhendler
Jun 27, 2008·Cornea·Takahiko HayashiNobuhisa Mizuki
Feb 10, 2021·Pathology·Katherine AntelE Verburgh
Oct 17, 1998·La Revue de médecine interne·R CostelloJ A Gastaut