Human Immunodeficiency Virus-Associated Myocardial Diastolic Dysfunction and Soluble ST2 Concentration in Tanzanian Adults: A Cross-Sectional Study.

The Journal of Infectious Diseases
Justin R KingeryRobert Peck

Abstract

The aims of this study were (1) to compare the prevalence of myocardial diastolic dysfunction (DD) in antiretroviral therapy (ART)-naive people living with human immunodeficiency virus (PLWH) to human immunodeficiency virus (HIV)-uninfected adults in East Africa and (2) to determine the association between serum concentration of the cardiac biomarkers ST2 and DD. In this cross-sectional study, we enrolled PLWH and uninfected adults at a referral HIV clinic in Mwanza, Tanzania. Standardized history, echocardiography, and serum were obtained. Regression models were used to quantify associations. We enrolled 388 ART-naive PLWH and 461 HIV-uninfected adults with an average age of 36.0 ± 10.2 years. Of PLWH in the third, fourth, and fifth decades of life, 5.0%, 12.5%, and 32.7%, respectively, had DD. PLWH had a higher prevalence of DD (adjusted odds ratio, 2.71 [95% confidence interval, 1.62-4.55]; P < .0001). PLWH also had a higher probability of dysfunction with one or fewer traditional risk factors present. Serum ST2 concentration was associated with dysfunction in PLWH but not uninfected participants (P = .04 and P = .90, respectively). In a large population of young adults in sub-Saharan Africa, DD prevalence increased starting...Continue Reading

References

Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Sep 19, 2003·Lancet·Marc A PfefferUNKNOWN CHARM Investigators and Committees
Feb 18, 2004·Hypertension·Fumitaka KuwaharaTsutomu Imaizumi
Apr 26, 2007·The Journal of Clinical Endocrinology and Metabolism·Virginia A TriantSteven K Grinspoon
May 12, 2007·The Journal of Clinical Investigation·Shoji SanadaRichard T Lee
Apr 9, 2008·The American Journal of Cardiology·Iris SchusterPhilippe Obert
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Mar 10, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sherif F NaguehArturo Evangelisa
Mar 14, 2009·AIDS Patient Care and STDs·Gautam NayakCatherine F Decker
Oct 8, 2009·Circulation. Heart Failure·Tatiana KuznetsovaJan A Staessen
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariola Kurowska-StolarskaFoo Y Liew
Nov 26, 2009·Circulation. Heart Failure·Priscilla Y HsueAnn F Bolger
Feb 16, 2010·Journal of the American College of Cardiology·Walter J Paulus, Joris J M van Ballegoij
Jan 11, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kristin E MondyUNKNOWN SUN Study Investigators
Aug 25, 2011·JAMA : the Journal of the American Medical Association·Garvan C KaneRichard J Rodeheffer
Nov 3, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stefan EsserNico Reinsch
Jun 25, 2013·Current HIV/AIDS Reports·Virginia A Triant
Apr 11, 2014·The New England Journal of Medicine·Bertram PittUNKNOWN TOPCAT Investigators
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt
Mar 10, 2015·Cardiovascular Drugs and Therapy·Ricardo Fontes-CarvalhoAdelino Leite-Moreira
Aug 8, 2015·JACC. Heart Failure·Gerald S BloomfieldEric J Velazquez
Aug 3, 2016·Journal of the American Heart Association·Ravi H ParikhChristopher R deFilippi
Jan 7, 2017·Journal of the American College of Cardiology·Sumbal A JanjuaTomas G Neilan
Mar 21, 2017·Current Atherosclerosis Reports·Revery P BarnesHossein Bahrami
Apr 30, 2017·Biochemical Pharmacology·Punniyakoti T VeeraveeduTetsuo Minamino
Jun 2, 2017·Disease Markers·Anca Daniela FarcaşMirela Anca Stoia
Dec 17, 2017·Immunological Reviews·Corinne Cayrol, Jean-Philippe Girard
Jan 18, 2018·The Journal of Experimental Medicine·Maarten HulsmansMatthias Nahrendorf
Feb 2, 2019·JACC. Heart Failure·Sebhat ErqouAndre Pascal Kengne
Nov 11, 2019·International Journal of Cardiology·Panagiotis SavvoulidisAndreas P Kalogeropoulos

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.