PMID: 9525661Apr 3, 1998Paper

Human immunodeficiency virus neurotropism: an analysis of viral replication and cytopathicity for divergent strains in monocytes and microglia

Journal of Virology
A GhorpadeHoward E Gendelman

Abstract

Productive replication of human immunodeficiency virus type 1 (HIV-1) in brain macrophages and microglia is a critical component of viral neuropathogenesis. However, how virus-macrophage interactions lead to neurological disease remains incompletely understood. Possibly, a differential ability of virus to replicate in brain tissue macrophages versus macrophages in other tissues underlies HIV-1 neurovirulence. To these ends, we established systems for the isolation and propagation of pure populations of human microglia and then analyzed the viral life cycles of divergent HIV-1 strains in these cells and in cultured monocytes by using identical viral inocula and indicator systems. The HIV-1 isolates included those isolated from blood, lung tissue, cerebrospinal fluids (CSF), and brain tissues of infected subjects: HIV-1(ADA) and HIV-1(89.6) (from peripheral blood mononuclear cells), HIV-1(DJV) and HIV-1(JR-FL) (from brain tissue), HIV-1(SF162) (from CSF), and HIV-1(BAL) (from lung tissue). The synthesis of viral nucleic acids and viral mRNA, cytopathicity, and release of progeny virions were assessed. A significant heterogeneity among macrophage-tropic isolates for infection of monocytes and microglia was demonstrated. Importantl...Continue Reading

References

Jun 1, 1992·European Journal of Immunology·A MarchantM Goldman
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M I BukrinskyM Stevenson
Aug 1, 1985·Human Pathology·L R SharerL G Epstein
Jul 11, 1986·Science·S GartnerM Popovic
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C A WileyM B Oldstone
Apr 1, 1988·Brain Research·F L Jordan, W E Thomas
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W S PearD Baltimore
Sep 1, 1994·Journal of Neuropathology and Experimental Neurology·E UlvestadH Nyland
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·A G BukrinskayaM Stevenson
Apr 10, 1996·AIDS Research and Human Retroviruses·M Di StefanoF Chiodi
Apr 10, 1996·AIDS Research and Human Retroviruses·R T ReddyC A Wiley

❮ Previous
Next ❯

Citations

Sep 10, 2003·Journal of Leukocyte Biology·Woong-Ki KimKenneth Williams
Sep 8, 2006·Journal of Virology·Erik S ZimmermanVicente Planelles
Jul 19, 2002·The Journal of General Virology·Paul R Clapham, Aine McKnight
Aug 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J C Martín, J C Bandrés
Sep 16, 2006·Immunological Reviews·Yuri Persidsky, Larisa Poluektova
Sep 29, 2011·Neurotoxicity Research·Italo MocchettiValeriya Avdoshina
Jul 8, 2020·International Journal of Molecular Sciences·Slava RomYuri Persidsky
Aug 13, 1999·AIDS Research and Human Retroviruses·S HibbittsP R Clapham
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessia VeraniDonata Vercelli
Mar 7, 2013·Journal of Leukocyte Biology·Servio H RamirezYuri Persidsky
Jun 7, 2016·Reviews in Medical Virology·Rui SoaresTeresa Gonçalves
Jun 8, 2002·Annual Review of Neuroscience·Kenneth C Williams, William F Hickey
Jun 21, 2015·Journal of Neurovirology·Frances ZenónLoyda M Melendez
Oct 12, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Omar Vélez LópezLoyda M Meléndez
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rebecca L DunfeeDana Gabuzda
Jul 10, 1999·Journal of Virology·S W DowE A Hoover
Dec 8, 2004·Journal of Neuroimmunology·Shilpa BuchOpendra Narayan
Jun 19, 2010·Molecular Aspects of Medicine·Vicente Planelles, Edward Barker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.