Human immunodeficiency virus type 1--serodiscordant couples can bear healthy children after undergoing intrauterine insemination

Fertility and Sterility
S MarinaA Vergés

Abstract

To use semen from men who were seropositive for human immunodeficiency virus type 1 (HIV-1) to inseminate their partners without infecting them. Prospective study. Private practice. Sixty-three HIV-1-seropositive men and their HIV-1-seronegative female partners. The men provided 107 semen samples that were prepared with the use of the Percoll and swim-up techniques. The presence of HIV-1 was determined in the fraction of motile spermatozoa obtained after washing. If HIV-1 was not detected. IUI was performed in stimulated cycles. Human immunodeficiency virus type 1 RNA and DNA were detected with the use of the polymerase chain reaction technique modified for spermatozoa. One hundred seven semen samples were washed. Human immunodeficiency virus type 1 was not detected in 101 samples (94.4%) and was detected in 6 samples (5.6%). In the latter cases, IUI was not performed. One hundred one IUI procedures were performed in 63 women. Thirty-one pregnancies resulted, for a pregnancy rate of 30.7% per cycle and 49.2% per inseminated woman. Thirty-seven healthy children were born. The results of tests for the detection of HIV-1 and antibodies to HIV-1 in the inseminated women were negative. On the basis of these results, testing for HIV-...Continue Reading

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Citations

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Sep 15, 2004·Fertility and Sterility·UNKNOWN Ethics Committee of the American Society for Reproductive Medicine
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