Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processing

Journal of Virology
Peter C ChienCatarina E Hioe

Abstract

T-helper responses are important for controlling chronic viral infections, yet T-helper responses specific to human immunodeficiency virus type 1 (HIV-1), particularly to envelope glycoproteins, are lacking in the vast majority of HIV-infected individuals. It was previously shown that the presence of antibodies to the CD4-binding domain (CD4bd) of HIV-1 glycoprotein 120 (gp120) prevents T-helper responses to gp120, but their suppressive mechanisms were undefined (C. E. Hioe et al., J. Virol. 75:10950-10957, 2001). The present study demonstrates that gp120, when complexed to anti-CD4bd antibodies, becomes more resistant to proteolysis by lysosomal enzymes from antigen-presenting cells such that peptide epitopes are not released and presented efficiently by major histocompatibility complex class II molecules to gp120-specific CD4 T cells. Antibodies to other gp120 regions do not confer this effect. Thus, HIV may evade anti-viral T-helper responses by inducing and exploiting antibodies that conceal the virus envelope antigens from T cells.

References

Jun 1, 1992·AIDS Research and Human Retroviruses·S KarwowskaS Zolla-Pazner
Jul 1, 1989·The Journal of Cell Biology·H W Davidson, C Watts
Oct 1, 1993·The Journal of Experimental Medicine·C Watts, A Lanzavecchia
Jan 13, 2000·Immunological Reviews·T Y Nakagawa, A Y Rudensky
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·C CicalaA S Fauci
Mar 9, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·D FenoglioF Manca
Feb 7, 2001·Immunity·J A Villadangos, H L Ploegh
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·D G MyszkaM L Doyle
Mar 28, 2001·Science·P M RuddR A Dwek
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·S SurmanJ L Hurwitz
May 3, 2002·Nature·Daniel C DouekRichard A Koup
Oct 31, 2002·Nature Immunology·Jonathan W Yewdell, Ann B Hill
May 31, 2003·Nature Reviews. Immunology·Karen Honey, Alexander Y Rudensky
Oct 31, 2003·AIDS Research and Human Retroviruses·Sandra CohenCatarina E Hioe

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Citations

Mar 31, 2007·The EMBO Journal·Catherine X MossColin Watts
Aug 18, 2005·European Journal of Immunology·Michael TuenCatarina E Hioe
Nov 13, 2018·Frontiers in Immunology·Catarina E HioeSusan Zolla-Pazner
Aug 4, 2019·Journal of Virology·Johannes S GachDonald N Forthal
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hualin LiCatarina E Hioe

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