Human immunodeficiency virus type 1-infected persons with residual disease and virus reservoirs on suppressive highly active antiretroviral therapy can be stratified into relevant virologic and immunologic subgroups

The Journal of Infectious Diseases
G DornadulaRoger J Pomerantz

Abstract

A significant percentage of human immunodeficiency virus type 1 (HIV-1)-infected persons treated with highly active antiretroviral therapy (HAART) will develop plasma HIV-1-specific virion RNA levels <50 copies/mL. HIV-1-infected persons receiving virally suppressive HAART were studied with a viral outgrowth assay of the patients' peripheral blood mononuclear cells (PBMC), and a quantitative polymerase chain reaction assay was used to analyze HIV-1 2-long terminal repeat (2-LTR) circular DNA in PBMC, which indicates new HIV-1 infections of cells in vivo. Viral outgrowth in vitro correlated inversely with the level of peripheral blood CD4(+) T lymphocytes. Detection and quantitation of 2-LTR circular DNA correlated strongly with viral outgrowth patterns and inversely with CD4(+) T lymphocyte counts. Relevant subgroups of HIV-1-infected subjects on suppressive HAART with residual viral disease and reservoirs can now be stratified.

Citations

Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roger J Pomerantz
Sep 1, 2005·AIDS Research and Human Retroviruses·Giuseppe NunnariRoger J Pomerantz
Sep 28, 2002·AIDS·Hernan ValdezUNKNOWN AIDS Clinical Trials Group Protocol 375 Team
Dec 6, 2005·AIDS Research and Therapy·Pietro L Vernazza
Oct 13, 2005·AIDS Research and Therapy·Chong XuDeborah J Anderson
Nov 1, 2005·Expert Opinion on Biological Therapy·Giuseppe Nunnari, Roger J Pomerantz
Jun 19, 2013·Journal of Virological Methods·Yunden Badralmaa, Ven Natarajan
Feb 7, 2008·Expert Review of Vaccines·Andreas Boberg, Maria Isaguliants
Jan 31, 2018·Retrovirology·Javier Martinez-PicadoMario Stevenson
Jul 2, 2003·Nature Medicine·Roger J Pomerantz, David L Horn
Nov 26, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Carmen Muñoz-AlmagroC Latorre
Nov 19, 2003·Current Opinion in Infectious Diseases·Sunil Shaunak, Ian Teo

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