PMID: 9420266Jan 7, 1998Paper

Human immunodeficiency virus type 1 populations in blood and semen

Journal of Virology
E L DelwartM K Singh

Abstract

Transmission of human immunodeficiency virus type 1 (HIV-1) usually results in outgrowth of viruses with macrophage-tropic phenotype and consensus non-syncytium-inducing (NSI) V3 loop sequences, despite the presence of virus with broader host range and the syncytium-inducing (SI) phenotype in the blood of many donors. We examined proviruses in contemporaneous peripheral blood mononuclear cells (PBMC) and non-spermatozoal semen mononuclear cells (NSMC) of five HIV-1-infected individuals to determine if this preferential outgrowth could be due to compartmentalization and thus preferential transmission of viruses of the NSI phenotype from the male genital tract. Phylogenetic reconstructions of approximately 700-bp sequences covering the second constant region through the fifth variable region (C2 to V5) of the viral envelope gene revealed distinct variant populations in the blood versus the semen in two patients with AIDS and in one asymptomatic individual (patient 613), whereas similar variant populations were found in both compartments in two other asymptomatic individuals. Variants with amino acids in the V3 loop that predict the SI phenotype were found in both AIDS patients and in patient 613; however, the distribution of thes...Continue Reading

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Citations

Apr 15, 1999·AIDS·P L VernazzaM S Cohen
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·N Dejucq, B Jégou
Apr 12, 2003·AIDS Research and Human Retroviruses·Thomas E MullenAnn A Kiessling
Jun 14, 2003·AIDS Research and Human Retroviruses·Stephen TaylorDeenan Pillay
Mar 17, 2006·Nature Reviews. Microbiology·Leonid Margolis, Robin Shattock
Apr 23, 2008·AIDS Research and Human Retroviruses·Kurt DiemJohn N Krieger
Mar 19, 2008·PloS One·Anna Le TortorecNathalie Dejucq-Rainsford
Apr 3, 2009·Current Opinion in HIV and AIDS·Michael M Lederman, Jose Este
Sep 3, 2010·PLoS Pathogens·Jeffrey A AndersonUNKNOWN Center for HIV/AIDS Vaccine Immunology
Dec 31, 2010·Journal of Virology·Jesus F Salazar-GonzalezUNKNOWN Center for HIV/AIDS Vaccine Immunology A0167854
Jul 1, 2011·Future Virology·Maile Ay Karris, Davey M Smith
Apr 5, 2020·Sexually Transmitted Infections·Miguel Ángel López ZúñigaFederico Garcia
Sep 20, 2001·The Journal of General Virology·C CasadoC López-Galíndez
Oct 18, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·K R CollinsE J Arts
Jul 23, 2004·Evolution; International Journal of Organic Evolution·Rafael SanjuánSantiago F Elena
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Jan 15, 2005·Journal of Virology·Satish K PillaiDavey M Smith
Apr 15, 2003·Journal of Virology·David C NickleJames I Mullins
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Oct 20, 2012·American Journal of Reproductive Immunology : AJRI·Jackeline Soto-RiveraPhalguni Gupta
Dec 5, 2013·The Journal of Infectious Diseases·Antoine ChaillonDavid M Smith
Oct 12, 2002·Journal of Medical Virology·Bhudipa ChoudhuryPatricia A Cane
Nov 26, 2003·Journal of Evolutionary Biology·J M CuevasS F Elena

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