PMID: 9658084Jul 11, 1998Paper

Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels

Journal of Virology
L YinJ Luban

Abstract

Human immunodeficiency virus type 1 (HIV-1) Gag and the cellular protein cyclophilin A form an essential complex in the virion core: virions produced by proviruses encoding Gag mutants with decreased cyclophilin A affinity exhibit attenuated infectivity, as do virions produced in the presence of the competitive inhibitor cyclosporine. The A224E Gag mutant has no effect on cyclophilin A affinity but renders HIV-1 replication cyclosporine resistant in Jurkat T cells. In contrast, A224E mutant virus is dead in H9 T cells, although replication is rescued by cyclosporine or by expression in cis of a Gag mutant that decreases cyclophilin A-affinity. The observation that disruption of the Gag-cyclophilin A interaction rescues A224E mutant replication in H9 cells prompted experiments which revealed that, relative to Jurkat cells, H9 cells express greater quantities of cyclophilin A. The resulting larger quantity of cyclophilin A shown to be packaged into virions produced by H9 cells is presumably disruptive to the A224E mutant virion core. Further evidence that increased cyclophilin A expression in H9 cells is of functional relevance was provided by the finding that Gag mutants with decreased cyclophilin A affinity are dead in Jurkat c...Continue Reading

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Citations

Feb 26, 2000·Annual Review of Genetics·H TangF Wong-Staal
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·T PushkarskyM Bukrinsky
Dec 1, 2001·Expert Opinion on Biological Therapy·B G Brenner, Z Wainberg
Mar 8, 2020·Virology Journal·Zachary IngramAmy E Hulme
Jan 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Neeltje A KootstraInder M Verma
Oct 14, 2004·Journal of Virology·Yasuhiro IkedaGreg J Towers
May 14, 2005·Journal of Virology·Réjean CantinMichel J Tremblay
Mar 12, 2010·Journal of Virology·Marisa S BrionesSamson A Chow
Oct 13, 2010·The Journal of Biological Chemistry·Luciano VozzoloAriberto Fassati
Jul 17, 2015·Nature Reviews. Microbiology·Edward M Campbell, Thomas J Hope
Nov 16, 2004·Journal of Virology·Elena SokolskajaJeremy Luban
Jul 4, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P C Kuo, P G Stock
Jan 24, 2008·Antimicrobial Agents and Chemotherapy·Roger G PtakBrigitte Rosenwirth
Apr 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Donatella CiuffredaManuel Pascual
Jul 30, 2009·Proteomics·Jérôme DenardFedor Svinartchouk
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Oct 18, 2002·Antimicrobial Agents and Chemotherapy·Jocelyn RoyMichel J Tremblay
Jan 12, 2021·Computational and Structural Biotechnology Journal·Firdaus SamsudinPeter J Bond

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