Human immunodeficiency virus type 1-specific immune responses in primates upon sequential immunization with adenoviral vaccine carriers of human and simian serotypes

Journal of Virology
Arturo Reyes-SandovalH C J Ertl

Abstract

Two triple immunization vaccine regimens with adenoviral vectors with E1 deleted expressing Gag of human immunodeficiency virus type 1 were tested for induction of T- and B-cell-mediated-immune responses in mice and in nonhuman primates. The vaccine carriers were derived from distinct serotypes of human and simian adenoviruses that fail to elicit cross-neutralizing antibodies expected to dampen the effect of booster immunizations. Both triple immunization regimens induced unprecedented frequencies of gamma interferon-producing CD8(+) T cells to Gag in mice and monkeys that remained remarkably stable over time. In addition, monkeys developed Gag-specific interleukin-2-secreting T cells, presumably belonging to the CD4(+) T-cell subset, and antibodies to both Gag and the adenoviral vaccine carriers.

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Citations

May 19, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hua LiHildegund C J Ertl
Dec 12, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dongming ZhouHildegund C J Ertl
Apr 7, 2005·Nature Medicine·Harriet L Robinson, Rama Rao Amara
Jul 18, 2006·Nature Medicine·Luk H VandenbergheJames M Wilson
Feb 24, 2006·Nature Reviews. Immunology·Adrian V S Hill
Dec 2, 2005·Gene Therapy·N TatsisH C J Ertl
Jan 20, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Scott E HensleyHildegund C J Ertl
Dec 6, 2007·The Journal of Infectious Diseases·Steven M JonesHeinz Feldmann
Dec 22, 2004·Human Gene Therapy·Michael J McConnell, Michael J Imperiale
Mar 12, 2005·Human Gene Therapy·Julie L BoyerRonald G Crystal
Dec 21, 2006·Emerging Infectious Diseases·Zhiquan XiangHildegund C J Ertl
Jan 1, 2011·Therapeutic Delivery·Anja Krause, Stefan Worgall
Oct 30, 2010·Nature Protocols·Dongming ZhouHildegund C J Ertl
Apr 29, 2009·Expert Review of Vaccines·Katarina RadosevićJaap Goudsmit
Apr 9, 2008·Expert Review of Vaccines·Tomás Hanke
Dec 24, 2005·Expert Opinion on Biological Therapy·Dongming Zhou, Hildegund C J Ertl
Apr 26, 2011·Current Opinion in Immunology·Christine S RollierAdrian V S Hill
Apr 28, 2007·Immunology·Arturo Reyes-SandovalStephen M Todryk
Sep 29, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lasse VinnerAnders Fomsgaard
Jan 7, 2015·The Journal of Pharmacy and Pharmacology·Lynda CoughlanSarah Gilbert
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Nov 22, 2005·Vaccine·Dinesh S Bangari, Suresh K Mittal
May 14, 2005·Microbes and Infection·Helen McShane, Adrian Hill

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