Human immunoglobulin G responses to Cimex lectularius L. saliva.

Parasite Immunology
Johnathan M SheeleThomas S McCormick

Abstract

To investigate the immunoglobulin (Ig) G response after being fed upon by Cimex lectularius L. Participants were fed upon by three male C lectularius insects weekly for a month. Blood was obtained before the feeding and at the last feeding, which was used for immunoblots against bed bug salivary gland extract, with antihuman Immunoglobulin G (IgG) secondary antibodies. No consistent IgG changes developed in 11 humans serially fed upon by C lectularius. Two participants had new IgG responses to proteins at molecular weights of approximately 12-13 kDa, and one had an IgG response to a protein at approximately 40 kDa. At the last study visit, more intense IgG bands to proteins at molecular weights of 12-13 kDa had developed in 55% of participants (6/11) and at molecular weights of ≈30, ≈40 and ≈70 kDa in 45% (5/11) compared with the first study visit. Nitrophorin and apyrase were the most common C lectularius proteins identified with liquid chromatography-tandem mass spectrometry in both crushed bed bug salivary gland extract and post-bed bug feeding extract. Human participants did not have consistent IgG responses to crushed C lectularius salivary gland extract.

References

Feb 14, 2004·International Archives of Allergy and Immunology·Zhikang Peng, F Estelle R Simons
Mar 12, 2004·European Journal of Epidemiology·T Nebreda MayoralR Pérez-Sánchez
Jan 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrzej WeichselWilliam R Montfort
Jan 19, 2006·The Journal of Investigative Dermatology·Martin LeverkusAxel Trautmann
Jan 21, 2006·Parasitology Research·Mohamed Badawy Abdel-NaserNehad Mahmoud Sayed Ali
Mar 19, 2009·Medical and Veterinary Entomology·K ReinhardtM T Siva-Jothy
May 6, 2010·Journal of Proteome Research·Ivo M B FrancischettiJosé M C Ribeiro
Jul 3, 2010·Journal of Proteome Research·Laura Cassiday
Jan 11, 2012·Clinical Microbiology Reviews·Stephen L DoggettRichard C Russell
Feb 7, 2012·The Journal of Allergy and Clinical Immunology·Jason B PriceMatthew S Perzanowski
Apr 5, 2013·JAMA Dermatology·Jerome Goddard, Kristine T Edwards

❮ Previous
Next ❯

Citations

Mar 12, 2021·Parasite Immunology·Johnathan M Sheele

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Johnathan M SheeleNathan Morris
© 2022 Meta ULC. All rights reserved