Human in vivo study of the renin-angiotensin-aldosterone system and the sympathetic activity after 8 weeks daily intake of fermented milk

Clinical Physiology and Functional Imaging
L UsingerL T Jensen

Abstract

Milk fermented by lactic acid bacteria is suggested to have antihypertensive effect in humans. In vitro and animal studies have established an angiotensin-converting enzyme (ACE) inhibitor effect of peptides in fermented milk. However, other modes of action must be considered, because until today no human studies have confirmed an ACE inhibition in relation to the intake of fermented milk. We undertook a double-blinded randomized placebo-controlled study including 94 borderline-hypertensive persons to study the effect on human physiology of Lactobacillus helveticus fermented milk. The subjects were randomized into three groups: Cardi04-300 ml, Cardi04-150 ml or placebo. All components of the renin-angiotensin-aldosterone system were measured several times. Sympathetic activity was estimated by plasma noradrenaline and cardiovascular response to head-up tilt at baseline and after 8 weeks of intervention. No ACE inhibition of the fermented milk was demonstrated, as none of the components of the renin-angiotensin-aldosteron system changed. Plasma noradrenaline response to tilt test after intervention stayed unchanged between groups (P = 0.38), but declined in the group Cardi04-300 from 2.01 +/- 0.93 nmol l(-1) at baseline to 1.49 ...Continue Reading

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Citations

Jul 9, 2011·The British Journal of Nutrition·Pauliina I EhlersHeikki Vapaatalo
Jul 5, 2013·The British Journal of Nutrition·Jia-Yi DongYouyou Zhao
Mar 3, 2012·Current Cardiovascular Risk Reports·Mary M McGraneLinda Van Horn
Jan 1, 2013·Bioscience of Microbiota, Food and Health·Seitaro KamiyaMasayori Hagimori
Apr 10, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L-Q QinW Zhang
Sep 13, 2014·Acta Neurologica Scandinavica·C BackH K Iversen
Jun 2, 2015·Food & Function·Alice B Nongonierma, Richard J FitzGerald
Dec 16, 2017·Critical Reviews in Food Science and Nutrition·Melanie Martin, Andreas Deussen
Sep 26, 2017·Critical Reviews in Food Science and Nutrition·Nevin ŞanlierAybüke Ceyhun Sezgin
May 25, 2020·Nutrition Reviews·Dennis A Savaiano, Robert W Hutkins
Apr 27, 2020·Lipids in Health and Disease·Dan QiJian-Jun Zhang
Jul 30, 2019·Journal of Food Biochemistry·Rotimi E Aluko
Dec 28, 2010·Advances in Colloid and Interface Science·Blanca Hernández-LedesmaIsidra Recio

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