Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification.

Journal of Clinical Immunology
Aziz BousfihaStuart G Tangye

Abstract

Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification into ten tables. This phenotypic classification is user-friendly and serves as a resource for clinicians at the bedside. There are now 430 single-gene IEI underlying phenotypes as diverse as infection, malignancy, allergy, autoimmunity, and autoinflammation. We herein report the 2019 phenotypic classification, including the 65 new conditions. The diagnostic algorithms are based on clinical and laboratory phenotypes for each of the ten broad categories of IEI.

References

Aug 1, 2012·Journal of Clinical Immunology·Ahmed Aziz BousfihaLaurent Abel
Nov 27, 2016·Journal of Clinical Immunology·Leïla JeddaneAhmed Aziz Bousfiha
Dec 12, 2017·Journal of Clinical Immunology·Aziz BousfihaKathleen E Sullivan

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Citations

Aug 18, 2020·Cellular & Molecular Immunology·Emily S J EdwardsMenno C van Zelm
Sep 2, 2020·Scandinavian Journal of Immunology·Zahra AlizadehZahra Pourpak
May 21, 2020·Clinical & Translational Immunology·Jinqiao SunWenhao Zhou
Jul 6, 2020·Journal of Clinical Immunology·Khusan KhodzhaevMuge Sayitoglu
Jun 11, 2020·Blood·Jarmila Stremenova SpegarovaSophie Hambleton
Jun 20, 2020·Nature Reviews. Immunology·Shen-Ying ZhangUNKNOWN COVID Team
Jul 25, 2020·JAMA : the Journal of the American Medical Association·Caspar I van der MadeAlexander Hoischen
Apr 17, 2020·Frontiers in Immunology·Luke A WallRicardo U Sorensen
Jul 7, 2020·Frontiers in Immunology·Sophie JungAurélien Guffroy
Sep 26, 2020·Science·Qian ZhangJean-Laurent Casanova
Sep 15, 2020·Journal of Clinical Immunology·Vincent R Bonagura, Jean-Laurent Casanova
Aug 9, 2020·The Journal of Experimental Medicine·Carla Noemi CastroSeiamak Bahram
Sep 6, 2020·Scandinavian Journal of Immunology·Sandro F PerazzioMikko R J Seppänen
Oct 12, 2020·Journal of Clinical Immunology·Asena Pınar SeferSafa Baris
Oct 13, 2020·Current Opinion in Allergy and Clinical Immunology·Ludmila PerelyginaKathleen E Sullivan
Dec 1, 2020·Journal of Participatory Medicine·Shouling ZhangArtemio M Jongco Iii
Nov 11, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Federica ForlaniniMorna J Dorsey
Sep 23, 2020·Minerva pediatrica·Enrica CalzoniSilvia C Giliani
Dec 19, 2020·British Journal of Haematology·Thomas A Fox, Claire Booth
Jan 7, 2021·Allergy and Asthma Proceedings·Michelle DilleyBob Geng
Jan 8, 2021·Journal of Clinical Immunology·Ibtihal BenhsaienAhmed Aziz Bousfiha
Sep 28, 2020·The Journal of Allergy and Clinical Immunology·Isabelle MeytsStuart G Tangye
Jan 6, 2021·Jornal de pediatria·Anete Sevciovic Grumach, Ekaterini Simões Goudouris
Dec 11, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nurhan KasapSafa Baris
Dec 29, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Jocelyn R Farmer, Gulbu Uzel
Dec 18, 2020·Immunology Letters·Suran L FernandoJamma Li
Apr 15, 2020·Annual Review of Pathology·Jean-Laurent Casanova, Laurent Abel
Oct 7, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Manfred HoenigAnsgar S Schulz
Feb 4, 2021·Seminars in Immunopathology·Rosa Bacchetta, Kenneth Weinberg
Feb 6, 2021·The Journal of Experimental Medicine·Paul BastardJean-Laurent Casanova
Dec 6, 2020·Nature Reviews. Genetics·Andrew J KwokJulian C Knight
Dec 29, 2020·Critical Reviews in Clinical Laboratory Sciences·Laura Casamayor-PoloLuis M Allende
Dec 7, 2020·British Journal of Haematology·Neelam PanchalClaire Booth
Feb 9, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Roshini S Abraham, Manish J Butte

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