Human induced pluripotent stem cells: a review of the US patent landscape

Regenerative Medicine
Bilyana P Georgieva, Jane M Love

Abstract

Human induced pluripotent stem (iPS) cells and human embryonic stem cells are cells that have the ability to differentiate into a variety of cell types. Embryonic stem cells are derived from human embryos; however, by contrast, human iPS cells can be obtained from somatic cells that have undergone a process of 'reprogramming' via genetic manipulation such that they develop pluripotency. Since iPS cells are not derived from human embryos, they are a less complicated source of human pluripotent cells and are considered valuable research tools and potentially useful in therapeutic applications in regenerative medicine. Worldwide, there are only three issued patents concerning iPS cells. Therefore, the patent landscape in this field is largely undefined. This article provides an overview of the issued patents as well as the pending published patent applications in the field.

References

Nov 6, 1998·Science·J A ThomsonJ M Jones
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J ShamblottJ D Gearhart
Jan 18, 2006·Science·Donald Kennedy
Nov 22, 2007·Science·Junying YuJames A Thomson
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Oct 14, 2008·Nature Biotechnology·Danwei HuangfuDouglas A Melton
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Nov 10, 2009·Nature Biotechnology·Sarah Webb
Nov 17, 2009·Cell·Christiane Druml

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Citations

Jul 17, 2010·Regenerative Medicine·M William Lensch, Mahendra Rao
May 9, 2014·Journal of Ayurveda and Integrative Medicine·Kalpana S Joshi, Ramesh Bhonde
Aug 6, 2014·Nature Biotechnology·Peter W AndrewsShinya Yamanaka
Apr 4, 2015·Regenerative Medicine·Mahendra RaoSusan Solomon
Jun 12, 2013·Cell Stem Cell·Sandra J Engle, Dinesh Puppala
Feb 28, 2015·Stem Cells Translational Medicine·Melissa K Carpenter, Mahendra S Rao
Dec 6, 2014·Toxicologic Pathology·Joydeep BasuMahendra Rao
Jun 18, 2017·Regenerative Medicine·Andreia Martins Martinho, Leigh Turner

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Methods Mentioned

BETA
genetic modification
transgenic
transfection
PCR

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