Human-induced pluripotent stem cells as models for rare cardiovascular diseases: from evidence-based medicine to precision medicine.

Pflügers Archiv : European journal of physiology
Ziwei PanPing Liang

Abstract

Rare cardiovascular diseases (RCDs) refer to those cardiovascular diseases that display a low prevalence as well as morbidity. Due to the vast variety of underlying genetic mutations and the relatively low patient population, RCDs present additional challenges for diagnosis. Precision medicine may offer opportunities for designing patient-specific therapies in particular for carriers of variants with undetermined significance. Moreover, precision medicine strategies provide benefit to patients with "common" symptoms but carry in rare genetic variants. Induced pluripotent stem cells (iPSCs) present a state-of-the-art precision medicine approach which recently made contributions to the study of RCDs via patient-specific iPSC-derived cardiomyocytes (iPSC-CMs). Human iPSC-CMs are derived from a patient's somatic cells and thus recapitulate a personalized genomics background, serving as patient-specific disease models. In light of these advantages, iPSC-CMs evolved as an effective tool for modeling cardiac disease phenotypes and accurately evaluating the toxicity of potential therapeutic compounds. This review covers approaches for studying RCDs and iPSC-CM models generated so far for different RCDs, such as long QT syndrome (LQT), ...Continue Reading

References

Jul 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T EschenhagenE L Elson
Nov 6, 1998·Science·J A ThomsonJ M Jones
Feb 15, 2001·Cardiology·I GussakP Bjerregaard
Mar 18, 2003·The Journal of Clinical Investigation·Kobra HaghighiEvangelia G Kranias
Apr 20, 2004·Journal of the American College of Cardiology·Fiorenzo GaitaChristian Wolpert
Apr 21, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·David J TesterMichael J Ackerman
Apr 3, 2008·Nature Clinical Practice. Cardiovascular Medicine·Mark M AwadDaniel P Judge
Jul 19, 2008·Progress in Cardiovascular Diseases·Nian LiuSilvia G Priori
Oct 21, 2009·Circulation·Peter J SchwartzCarla Spazzolini
Dec 25, 2009·Circulation. Cardiovascular Genetics·Dan HuCharles Antzelevitch
Jul 28, 2010·The New England Journal of Medicine·Alessandra MorettiKarl-Ludwig Laugwitz
Nov 26, 2010·Orphanet Journal of Rare Diseases·Dominique P Germain
Jan 18, 2011·Nature·Ilanit ItzhakiLior Gepstein
Mar 19, 2011·Circulation Research·Christine E Seidman, J G Seidman
Aug 4, 2011·European Heart Journal·Daniel Jacoby, William J McKenna
Nov 5, 2011·Journal of Cellular and Molecular Medicine·Atara NovakOfer Binah
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Azra FatimaTomo Saric
Apr 5, 2012·Circulation·Andrew J Sauer, Christopher Newton-Cheh
Apr 21, 2012·Science Translational Medicine·Ning SunJoseph C Wu
Jun 29, 2012·Cardiovascular Research·Toru EgashiraKeiichi Fukuda
Jul 4, 2012·Journal of the American College of Cardiology·Ilanit ItzhakiLior Gepstein
Aug 14, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Divya RajamohanChris Denning
Sep 28, 2012·Frontiers in Physiology·Maaike HoekstraArie O Verkerk
Jan 2, 2013·The Journal of General Physiology·Cecile TerrenoireRobert S Kass
Jan 29, 2013·Nature·Changsung KimHuei-Sheng Vincent Chen
Jul 9, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Christine Y IvashchenkoRobert N Willette
Sep 4, 2013·Nature Reviews. Genetics·Kym M BoycottAlex E MacKenzie
Nov 10, 2013·Circulation. Cardiovascular Genetics·Oren CaspiLior Gepstein

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Mar 23, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Li-Yen WongMiranda Nabben
May 26, 2021·Pflügers Archiv : European journal of physiology·Xiao-Ling LuoHuang-Tian Yang

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