Human infant saliva peptidome is modified with age and diet transition

Journal of Proteomics
Martine MorzelPatrick Ducoroy

Abstract

In order to describe developmental changes in human salivary peptidome, whole saliva was obtained from 98 infants followed longitudinally at 3 and 6months of age. Data on teeth eruption and diet at the age of 6months were also recorded. Salivary peptide extracts were characterised by label-free MALDI-MS. Peptides differentially expressed between the two ages, and those significantly affected by teeth eruption or introduction of solid foods were identified by MALDI TOF-TOF and LC ESI MS-MS. Out of 81 peaks retained for statistical analysis, 26 were overexpressed at the age of 6months. Exposure to solid foods had a more pronounced effect on profiles (overexpression of nine peaks) than teeth eruption (overexpression of one peak). Differential peaks corresponded to fragments of acidic and basic PRPs, statherin and histatin. Comparison with existing knowledge on adult saliva peptidome revealed that proteolytic processing of salivary proteins is qualitatively quite comparable in infants and in adults. However, age and diet are modulators of salivary peptidome in human infants.

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Citations

Nov 20, 2013·European Journal of Pediatrics·M MorzelS Nicklaus
Oct 30, 2012·Clinical Biochemistry·Francisco M L AmadoRui Vitorino
Mar 13, 2015·Journal of Proteome Research·Irene MessanaMassimo Castagnola
Sep 5, 2015·PloS One·Caroline MéjeanGilles Feron
Mar 13, 2020·Metabolomics : Official Journal of the Metabolomic Society·Eric NeyraudCarole Tournier
Aug 9, 2016·Expert Review of Proteomics·Gavino FaaMassimo Castagnola
May 6, 2019·Chemical Senses·Laura E MartinAnn-Marie Torregrossa
May 6, 2017·Frontiers in Public Health·Mona Hassaneen, Jill L Maron
May 28, 2021·European Journal of Nutrition·Christophe ChambonMartine Morzel
Jun 4, 2019·Journal of Oral Microbiology·Alexander GardnerGuy H Carpenter

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