Human Infection Challenge Studies: a Test for the Social Value Criterion of Research Ethics.

MSphere
Nicholas G Evans

Abstract

Human infection challenge studies involving the intentional infection of research participants with a disease-causing agent have recently been suggested as a means to speed up the search for a vaccine for the ongoing coronavirus disease 2019 (COVID-19) outbreak. Calls for challenge studies, however, rely on the expected social value of these studies. This value represents more than the simple possibility that a successful study will lead to the rapid development and dissemination of vaccines but also some expectation that this will actually occur. I show how this expectation may not be realistic in the current political moment and offer potential ways to make sure that any challenge trials that arise actually achieve their goals.

References

Jun 1, 1992·Antiviral Research·D A Tyrrell
Oct 1, 1990·Epidemiology and Infection·K A CallowD A Tyrrell
Nov 1, 1983·Antimicrobial Agents and Chemotherapy·P G HigginsD A Tyrrell
Apr 20, 2001·Vaccine·J S MoynihanC R Howard
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F G Miller, C Grady
Jul 13, 2016·Journal of Medical Ethics·Regina Brown, Nicholas Greig Evans
Aug 18, 2016·Journal of Health Politics, Policy and Law·Efthimios Parasidis
Jan 26, 2017·Human Vaccines & Immunotherapeutics·Malcolm Molyneux
Jul 20, 2019·Clinical and Experimental Dermatology·M SławińskaM Sobjanek
Apr 1, 2020·The New England Journal of Medicine·Nicole LurieJane Halton
Apr 2, 2020·The Journal of Infectious Diseases·Nir EyalPeter G Smith
May 10, 2020·Science·Seema K ShahAnnette Rid
May 13, 2020·Science·Lawrence CoreyFrancis S Collins
Jun 2, 2020·The Lancet Infectious Diseases·Euzebiusz Jamrozik, Michael J Selgelid
Jun 28, 2020·AIDS and Behavior·Nir Eyal, Perry N Halkitis
Jul 1, 2020·Journal of the American Heart Association·Lingzhi LiQingyan Zhao

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Citations

Dec 29, 2020·Patient Preference and Adherence·Rana K Abu-FarhaOmar F Khabour
Oct 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey P KahnRuth Macklin

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