Human infection with a P[14], G3 lapine rotavirus

Virology
Karolien De LeenerMarc Van Ranst

Abstract

Group A rotaviruses are the main cause of severe diarrhoea in humans and animals throughout the world. We report the first description of a clinically apparent infection with a P[14], G3 rotavirus (strain B4106) in a hospitalized 6-year-old child. The VP7 gene of the B4106 strain had the closest sequence similarity (94% and 97% on the nucleotide and amino acid level, respectively) with strain 30/96 (P[14], G3), a lapine rotavirus isolated in an Italian rabbit in 1996 while the VP4 gene had the closest similarity with strain 30/96 on the nucleotide level (96%), and with lapine strains C-11 (P[14], G3) and Alabama (P[14], G3), isolated in the United States in the 1980s on the amino acid level (99%). The host restriction determinant gene NSP4 of B4106 was also most similar to lapine strain Alabama (95% nt identity and 97% aa identity). Phylogenetic analysis showed that the VP4, VP7, and NSP4 genes of the B4106 strain share a common evolutionary lineage with those of lapine rotavirus strains. We therefore hypothesize that a lapine rotavirus was able to cross the host species barrier and caused disease in a new host. The increasing detection of strains in humans that were previously believed to be restricted to animals raises questi...Continue Reading

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Citations

Jul 6, 2006·Applied and Environmental Microbiology·W B van ZylM B Taylor
Jan 7, 2006·The Pediatric Infectious Disease Journal·Ulrich DesselbergerTimo Vesikari
Feb 19, 2015·Viruses·Melisa Berenice BonicaElisabeth Heylen
Nov 1, 2005·Veterinary Microbiology·V MartellaC Buonavoglia
May 26, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jelle MatthijnssensMarc Van Ranst
Jan 3, 2012·Research in Veterinary Science·L C SilvaJ A Jerez

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