Human influenza viral infection in utero increases nNOS expression in hippocampi of neonatal mice

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S Hossein FatemiD Kist

Abstract

We investigated the role of maternal exposure to human influenza virus (HI) in C57BL/6 mice on day 9 of pregnancy on hippocampal expression of nNOS in day 0 neonates and compared that to sham-infected pups. Qualitative analysis using polyclonal antibody to nNOS showed overall increases in immunoreactivity (IR) in hippocampal and dentate layers of day 0 infected neonates when compared to sham-infected animals. These increases in nNOS immunoreactivity were pronounced in hippocampal plate, intermediate, molecular, subplate, and dentate areas. Quantitative analysis of specific immunogold silver-enhanced nNOS IR via densitometry showed nNOS IR increases of 26-71.6% in all layers, i.e., hippocampal plate (35.1%), dentate area (71.6%), molecular area (43.75%), subplate (45.7%), and intermediate zone (26%) in infected neonatal brains vs. controls. The changes in levels of nNOS expression in hippocampi of neonates born to mothers exposed to HI virus during the second trimester of pregnancy may reflect the potential for glutamatergic excitotoxicity via activation of NMDA receptors in the developing brains of these neonatal mice.

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Citations

Oct 16, 2010·Psychopharmacology·Julie A Markham, James I Koenig
Apr 15, 2008·Schizophrenia Bulletin·Urs MeyerBenjamin K Yee
Apr 8, 2014·Viral Immunology·Sandeep R P KumarSubbiah Elankumaran
Oct 28, 2009·Progress in Neurobiology·Urs Meyer, Joram Feldon
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Urs MeyerJoram Feldon
Oct 15, 2014·Nature Reviews. Neurology·Irene KnueselEric P Prinssen
Mar 27, 2003·Neuroreport·Håkan Karlsson
Jun 28, 2015·Experimental Parasitology·Gungor Cagdas Dincel, Hasan Tarik Atmaca

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