Human Innate Lymphoid Cells: Their Functional and Cellular Interactions in Decidua

Frontiers in Immunology
Paola VaccaLorenzo Moretta

Abstract

Innate lymphoid cells (ILC) are developmentally related cell subsets that play a major role in innate defenses against pathogens, in lymphoid organogenesis and in tissue remodeling. The best characterized ILC are natural killer (NK) cells. They are detectable in decidua in the early phases of pregnancy. During the first trimester, NK cells represent up to 50% of decidua lymphocytes. Differently from peripheral blood (PB) NK cells, decidual NK (dNK) cells are poorly cytolytic, and, instead of IFNγ, they release cytokines/chemokines that induce neo-angiogenesis, tissue remodeling, and placentation. dNK interact with resident myeloid cells and participate in the induction of regulatory T cells that play a pivotal role in maintaining an efficient fetal-maternal tolerance. dNK cells may originate from CD34+ precursor cells present in situ and/or from immature NK cells already present in endometrial tissue and/or from PB NK cells migrated to decidua. In addition to NK cells, also ILC3 are present in human decidua during the first trimester. Decidual ILC3 include both natural cytotoxic receptor (NCR)+ and NCR- cells, producing respectively IL-8/IL-22/GM-CSF and TNF/IL-17. NCR+ILC3 have been shown to establish physical and functional i...Continue Reading

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Citations

Jan 23, 2020·Cellular and Molecular Life Sciences : CMLS·Xing-Liang FanQing-Ling Fu
Jun 13, 2020·International Reviews of Immunology·Xiaopeng LiBolan Yu
Jul 14, 2020·Frontiers in Immunology·Anja Schulz-KuhntImke Atreya
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Feb 26, 2019·Frontiers in Immunology·Paola VaccaLorenzo Moretta
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Jul 6, 2019·Frontiers in Immunology·Andrea BaloghNandor Gabor Than
Sep 18, 2020·Placenta·Orestis TsonisPanagiotis Kanavaros
Dec 18, 2020·Frontiers in Immunology·Gabriel Mayoral AndradeEduardo Pérez-Campos
Oct 27, 2020·Frontiers in Immunology·Emily F CornishThomas McDonnell
Jul 3, 2021·Cells·Dorota M Radomska-LeśniewskaPaweł Kamiński
Aug 17, 2021·Frontiers in Immunology·Marie-Pierre PiccinniJulia Szekeres-Bartho

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