Human, insect and nematode caspases kill Saccharomyces cerevisiae independently of YCA1 and Aif1p

Apoptosis : an International Journal on Programmed Cell Death
Michelle A Puryer, C J Hawkins

Abstract

This study characterised the impact of active metazoan apoptotic proteases (caspases) on Saccharomyces cerevisiae viability. Expression of active caspase-3 or caspase-8 in yeast ruptured plasma and nuclear membranes and dramatically impaired clonogenic survival, but did not damage DNA. Deletion of the proposed yeast apoptosis regulators YCA1 or Aif1p did not affect the ability of human, insect or nematode caspases to kill yeast. These data indicate that expression of active metazoan caspases causes irreversible damage to yeast membranes and organelles, in a manner independent of YCA1 and Aif1p.

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Citations

Nov 17, 2009·Cell Death and Differentiation·M T Greenwood, P Ludovico
May 4, 2013·Cell Death & Disease·T E BeaumontC J Hawkins
Jan 9, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Clara PereiraLucília Saraiva
Jan 14, 2012·The FEBS Journal·Clara PereiraLucília Saraiva
Jan 27, 2009·Biochimica Et Biophysica Acta·Patricia Lisa-SantamaríaAlberto Jiménez
Mar 29, 2011·European Journal of Medicinal Chemistry·Paulo M C GlóriaMaria M M Santos
Mar 22, 2008·Biochimica Et Biophysica Acta·Cristina Mazzoni, Claudio Falcone
Mar 25, 2008·Biochimica Et Biophysica Acta·Qiuli LiangBing Zhou

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