Human interdigitating dendritic cells directly stimulate CD40-activated naive B cells

European Journal of Immunology
P BjörckY J Liu

Abstract

Human interdigitating dendritic cells (IDC) were isolated from tonsils based on their CD40+ lineage-negative expression in situ. Isolated IDC displayed a phenotypic profile similar to that of IDC in tonsils and spleen in situ, characterized by high-level expression of major histocompatibility complex class II, the co-stimulatory molecules B7.1 (CD80) and B7.2 (CD86), expression of the late DC maturation marker CD83, and no expression of CD1a, CD13, or CD33. IDC also showed weak nonspecific esterase staining and had the ability to induce an allogeneic mixed lymphocyte reaction. In this study, we further show that in the presence of surrogate activated T cells in the form of CD40 ligation and IL-2, IDC enhance the proliferation of naive B cells and induce their differentiation into plasma cells producing IgM. Evidence for the anatomical co-localization of naive B cells and IDC in the T cell area together with the data obtained in vitro implies a role for IDC in the initiation of the extrafollicular reaction.

References

Jan 1, 1991·Annual Review of Immunology·R M Steinman
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S Freudenthal, R M Steinman
Jul 1, 1988·The Journal of Experimental Medicine·D N Hart, J L McKenzie
Jan 1, 1989·Molecular Immunology·C FavreJ E de Vries
Aug 1, 1989·European Journal of Immunology·A ValléJ Banchereau
Jun 1, 1986·Immunological Reviews·I C MacLennan, D Gray
Apr 1, 1982·Immunobiology·E C HoefsmitE W Kamperdijk
Oct 1, 1994·The Journal of Experimental Medicine·C CauxJ Banchereau
May 5, 1995·Science·C ArpinY J Liu
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·D WeissmanA S Fauci

❮ Previous
Next ❯

Citations

Nov 11, 1999·European Journal of Immunology·C García De VinuesaI C MacLennan
Dec 19, 2001·The Journal of Pathology·Akitake SuzukiTakeshi Kasajima
Nov 9, 2011·International Journal of Colorectal Disease·Maya V GulubovaIrena M Manolova
Mar 9, 2006·Virchows Archiv : an International Journal of Pathology·Kiyoshi TakahashiKatsuya Miyatani
Jul 26, 2003·Developmental and Comparative Immunology·E F KrugerL M Pinchuk
Dec 14, 2002·Human Immunology·Pia Björck
Apr 12, 2001·Immunology·L Flores-Romo
Apr 13, 2000·Immunology and Cell Biology·L H StockwinG E Blair
Oct 3, 2002·International Immunology·Malin LindstedtCarl A K Borrebaeck
Jan 13, 2000·Immunological Reviews·G MacPhersonM Wykes
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·Tomoyoshi TsuchiyaHirotoshi Nakamura
Apr 4, 2001·The Journal of Clinical Investigation·N Bendriss-VermareF Brière
Oct 2, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hanako TakechiHiroo Kumagai
Aug 26, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yan-Hong NiYa-Yi Hou
Jun 29, 2004·Journal of Thrombosis and Haemostasis : JTH·P Lollar
Oct 7, 2008·Trends in Immunology·Jun KunisawaHiroshi Kiyono
Oct 29, 2005·Research in Veterinary Science·Kohtaro MiyazawaTakahiro Yamaguchi
Jul 5, 2001·The American Journal of Pathology·K L SummersD N Hart
Oct 18, 2005·Advances in Immunology·Francesca GranucciPaola Ricciardi-Castagnoli
Oct 5, 2016·Cellular Immunology·L MalaguarneraM Di Rosa
Aug 24, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jean-Jacques GovalLaurence de Leval
Oct 16, 2003·Shock·Philip Efron, Lyle L Moldawer
Jan 5, 2002·Physiological Reviews·Mary F Lipscomb, Barbara J Masten
Mar 10, 2001·Blood·S VandenabeeleK Shortman
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gouri ChattopadhyayClifford M Snapper
Apr 10, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Swagata KarClifford M Snapper
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B JohanssonC A Borrebaeck
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C G MuellerC Sautès-Fridman
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel EttingerPeter E Lipsky
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E LindhoutG J Adema
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ning-Na HuangJohn H Kehrl
May 11, 2021·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Vincenzo CapriottiGiancarlo Tirelli
Jan 10, 2002·Biochemical and Biophysical Research Communications·Zhuang ChenJim Xiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Jan-Willem EijgenraamC Van Kooten
Nephron. Experimental Nephrology
Elfriede NoessnerStephan Segerer
© 2021 Meta ULC. All rights reserved