PMID: 6977180Sep 1, 1981Paper

Human interleukin 2: production by both TG cells and other T cells

Scandinavian Journal of Immunology
A G SilvaM O de Landazuri

Abstract

We have investigated the production of interleukin 2 (IL-2) by human T cells after their stimulation by phytohaemagglutinin (PHA). T cells isolated by rosetting with sheep erythrocytes produced high levels of IL-2. Further separation of rosette-forming cells, according to the expression of Fc receptors for IgG, showed that TG and non-TG cells are equally able to produce IL-2. The release of IL-2 by TG cells did not require DNA synthesis or functional Rc gamma receptors, since positively selected TH cells produced IL-2, even though they lacked lymphoproliferative responses to PHA and antibody-dependent cell-mediated cytotoxicity.

References

Jun 1, 1979·The Journal of Experimental Medicine·S GillisK A Smith
Aug 1, 1979·International Journal of Cancer. Journal International Du Cancer·H D KayG D Bonnard
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S GuptaR A Good
Jan 1, 1975·European Journal of Immunology·M FerrariniM L Durante
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari

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