Human intestinal spirochetosis in Japanese patients aged less than 20 years: Histological analysis of colorectal biopsy and surgical specimens obtained from 479 patients

Pathology International
Shojiro IchimataTakayuki Honda

Abstract

Human intestinal spirochetosis (HIS) is a condition in which spirochetes attach to and colonize the colorectal epithelium. To our knowledge, no comprehensive studies of HIS in young patient have been published in a developed country. This study aimed to determine the incidence and clinicopathological manifestations of HIS in Japanese patients aged less than 20 years. We retrospectively reviewed 3605 biopsy and 92 surgical specimens obtained from 479 patients admitted to Shinshu University Hospital between 1997 and 2014. All slides were reviewed independently by two pathologists to confirm the histological presence of spirochetes. Among 387 patients who underwent biopsy, the most common pathologic diagnosis was ulcerative colitis (12.6%, n = 49). Additionally, about half of the biopsy specimens showed non-specific, mildly inflamed mucosa (50.6%, n = 196); only one of these cases was HIS. On the other hand, among the surgical specimens, we found no cases of HIS. We concluded that the incidence of HIS in Japanese young patients was 0.2% (1/479 cases). The incidence of HIS in Japanese young patients was very low, and one HIS case was associated with colitis with abdominal pain.

References

Sep 16, 1967·British Medical Journal·W A Harland, F D Lee
Mar 1, 1994·Pediatric Pathology·J WhiteE A Mitchell
Oct 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·R M da Cunha FerreiraJ A Walker-Smith
Sep 14, 2001·Journal of Gastroenterology and Hepatology·R G HeineD J Hampson
Oct 23, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lars MarthinsenGunilla Värendh
Jul 15, 2005·Journal of Food Protection·James L Smith
Oct 29, 2005·Journal of Pediatric Gastroenterology and Nutrition·Neil Ryan KingGlenn Gourley
Dec 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jin TanahashiShigeo Yokoyama
Jan 2, 2009·International Journal of Surgical Pathology·Norman J CarrRaghwa Sharma
Oct 20, 2009·Human Pathology·Sho OgataToshiaki Kawai
Mar 25, 2010·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·David F CarpentieriEmmanuel Siaw
Oct 17, 2012·BMC Pediatrics·Rossana HelblingAndreas Nydegger
Nov 26, 2015·Annals of Diagnostic Pathology·Sho OgataKuniaki Nakanishi

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Citations

Aug 14, 2019·Journal of Bacteriology·Steven J Norris
Mar 23, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Roel LemmensYvan Vandenplas

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