Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial

Journal of Clinical Periodontology
Francesco FerrarottiMario Aimetti

Abstract

The goal of this study was to evaluate if dental pulp stem cells (DPSCs) delivered into intrabony defects in a collagen scaffold would enhance the clinical and radiographic parameters of periodontal regeneration. In this randomized controlled trial, 29 chronic periodontitis patients presenting one deep intrabony defect and requiring extraction of one vital tooth were consecutively enrolled. Defects were randomly assigned to test or control treatments which both consisted of the use of minimally invasive surgical technique. The dental pulp of the extracted tooth was mechanically dissociated to obtain micrografts rich in autologous DPSCs. Test sites (n = 15) were filled with micrografts seeded onto collagen sponge, whereas control sites (n = 14) with collagen sponge alone. Clinical and radiographic parameters were recorded at baseline, 6 and 12 months postoperatively. Test sites exhibited significantly more probing depth (PD) reduction (4.9 mm versus 3.4 mm), clinical attachment level (CAL) gain (4.5 versus 2.9 mm) and bone defect fill (3.9 versus 1.6 mm) than controls. Moreover, residual PD < 5 mm (93% versus 50%) and CAL gain ≥4 mm (73% versus 29%) were significantly more frequent in the test group. Application of DPSCs signifi...Continue Reading

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Citations

Jun 12, 2019·International Journal of Molecular Sciences·Satoru Onizuka, Takanori Iwata
May 14, 2020·Stem Cell Research & Therapy·Yoichi YamadaShunsuke Baba
Jun 2, 2020·Frontiers in Immunology·Zhenkun WangSong Guo Zheng
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Nov 7, 2019·Stem Cells Translational Medicine·Federico Moreno SanchoFrancesco D'Aiuto
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Nov 3, 2020·Frontiers in Endocrinology·Jin LiYang Xia
Mar 7, 2021·Cells·Arkaitz MucientesBenjamín Fernández-Gutiérrez
Apr 4, 2021·International Journal of Environmental Research and Public Health·Guillermo Pardo-ZamoraAntonio J Ortiz-Ruíz
Apr 27, 2021·Journal of Clinical Periodontology·Danae A ApatzidouAntonis Konstantinidis
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Dixin CuiMian Wan
Jul 3, 2021·International Journal of Molecular Sciences·Sarah Hani ShoushrahEdda Tobiasch
Jun 25, 2021·Frontiers in Cell and Developmental Biology·Chao YangQiang Chen
Oct 26, 2020·Journal of Stomatology, Oral and Maxillofacial Surgery·T PourlakM Yousefi
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