PMID: 9428664Jan 15, 1998Paper

Human kallikrein hK2 has low kininogenase activity while prostate-specific antigen (hK3) has none

Biochimica Et Biophysica Acta
D DeperthesJ Y Dubé

Abstract

In the present paper, we determined the kinin-releasing activity of human prostatic kallikrein hK2 and compared it to one of the kallikreins hK1 and prostate specific antigen (hK3). Kinin-like substances active on the rabbit jugular vein were progressively produced when nanomolar concentrations of hK2 were incubated with heated plasma. However in these experiments, hK1 appeared much more potent than hK2 while hK3 was totally inactive. When hK2 was incubated with purified high molecular weight kininogen, several peptides were generated as shown by the analysis on C18 reverse-phase HPLC. Kinin activity was localized exclusively in a small peak having an elution time identical to that of bradykinin while the only important peak obtained with hK1 corresponded to Lys-bradykinin. Finally, the rate of kinin production of hK2 was found to be more than a thousandfold lower than that of hK1. These experiments show that kallikreins hK2 has only a low kininogenase activity. However, it is not excluded that some of the peptides produced by hK2 action could have other types of biological activity.

Citations

Sep 3, 2003·Clinical Biochemistry·George M Yousef, Eleftherios P Diamandis
Apr 7, 2000·Breast Cancer Research and Treatment·M H Black, E P Diamandis
Jan 20, 2004·European Journal of Biochemistry·Sylvain M CloutierDavid Deperthes
Mar 5, 2016·Expert Opinion on Therapeutic Targets·Margaritis Avgeris, Andreas Scorilas
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·S D MikolajczykM S Saedi
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven P BalkGlenn J Bubley
Oct 6, 1998·Critical Reviews in Clinical Laboratory Sciences·H G RittenhouseA W Partin
Aug 17, 2004·Critical Reviews in Clinical Laboratory Sciences·Judith A ClementsYing Dong
May 24, 2014·Biological Chemistry·Yijing YuEleftherios P Diamandis
Aug 30, 2000·Biochimica Et Biophysica Acta·M C Hsieh, B S Cooperman

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