Human keratinocytes release mast cell differentiation factors other than stem cell factor

International Archives of Allergy and Immunology
P WelkerB M Czarnetzki

Abstract

Besides stem cell factor (SCF), additional fibroblast-derived mast cell growth factors have previously been described. Since keratinocytes have also been shown to produce SCF, we have studied the ability of culture supernatants from the human HaCaT keratinocyte cell line to induce SCF-independent mast cell differentiation. The immature human mast cells of the HMC-1 line which express a mutant continuously activated SCF receptor were used as model target cells. Culture supernatants from differentiating keratinocytes (at day 11 of culture), and far less so those from proliferating keratinocytes (day 4 of culture), caused a marked, dose-dependent increase of histamine and tryptase in HMC-1 cells. This suggests that human HaCaT keratinocytes release mast cell differentiation factors other than SCF, to a degree related to their state of differentiation.

Citations

Aug 1, 1995·Experimental Dermatology·B M CzarnetzkiT Zuberbier
Aug 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M PompenR Lutter
Nov 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshifumi KimizukaSatoshi Kashiwagi
Mar 26, 2008·International Archives of Allergy and Immunology·Ji Young KimJai Youl Ro
Aug 23, 2003·The British Journal of Dermatology·Y Ashida, M Denda
May 14, 2004·Experimental Dermatology·Martin MetzRalf Paus

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